ID   A0A2M9J1J2_9ACTN        Unreviewed;       302 AA.
AC   A0A2M9J1J2;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   SubName: Full=Flap endonuclease {ECO:0000313|EMBL:PJN00749.1};
GN   ORFNames=CG740_22830 {ECO:0000313|EMBL:PJN00749.1};
OS   Streptomyces sp. CB01201.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2020324 {ECO:0000313|EMBL:PJN00749.1, ECO:0000313|Proteomes:UP000231916};
RN   [1] {ECO:0000313|Proteomes:UP000231916}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB01201 {ECO:0000313|Proteomes:UP000231916};
RA   Pan G., Xu Z., Guo Z., Ma M., Yang D., Zhou H., Gansemans Y., Zhu X.,
RA   Zhao L.-X., Jiang Y., Cheng J., van Nieuwerburgh F., Suh J.W., Duan Y.,
RA   Shen B.;
RT   "Discovery of the Leinamycin Family of Natural Products by Mining
RT   Actinobacterial Genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 114:0-0(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PJN00749.1}.
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DR   EMBL; NNBJ01000011; PJN00749.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2M9J1J2; -.
DR   OrthoDB; 9806424at2; -.
DR   Proteomes; UP000231916; Unassembled WGS sequence.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   CDD; cd09859; PIN_53EXO; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR038969; FEN.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   PANTHER; PTHR42646:SF2; DNA-DIRECTED DNA POLYMERASE; 1.
DR   PANTHER; PTHR42646; FLAP ENDONUCLEASE XNI; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Endonuclease {ECO:0000313|EMBL:PJN00749.1};
KW   Hydrolase {ECO:0000313|EMBL:PJN00749.1};
KW   Nuclease {ECO:0000313|EMBL:PJN00749.1}.
FT   DOMAIN          1..272
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00475"
SQ   SEQUENCE   302 AA;  32667 MW;  7F38EC3398767BE8 CRC64;
     MLLDTSSLFY RAYFGVPDTV RAPDGTPVNA VRGLLDFISR LVHDHRPDDL VACMDADWRP
     QWRVDLIPSY KAHRVAEETP AGQPDEEETP DTLAPQIPVI DDMLDALGIA RVGVDGYEAD
     DVIGTLSGLA PGPVDIVTGD RDLFQLVDDV RGVRVLYPRK GVGDCDLVDD ELIRTKYGVR
     PDQYADFAAL RGDTSDGLPG VKGIGEKTAA QLINEYGDLA GVRAAAADRF SKLTPAKRRG
     ILEAADYLDV APKVVRVAMD VPLPKFDPAL PTEPLDPATL EELVAQWGLA GATGRLLTTL
     RA
//