ID   A0A2M9J5I3_9ACTN        Unreviewed;       418 AA.
AC   A0A2M9J5I3;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=3-hydroxy-3-methylglutaryl-ACP synthase {ECO:0000313|EMBL:PJN02062.1};
GN   ORFNames=CG740_16915 {ECO:0000313|EMBL:PJN02062.1};
OS   Streptomyces sp. CB01201.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2020324 {ECO:0000313|EMBL:PJN02062.1, ECO:0000313|Proteomes:UP000231916};
RN   [1] {ECO:0000313|Proteomes:UP000231916}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB01201 {ECO:0000313|Proteomes:UP000231916};
RA   Pan G., Xu Z., Guo Z., Ma M., Yang D., Zhou H., Gansemans Y., Zhu X.,
RA   Zhao L.-X., Jiang Y., Cheng J., van Nieuwerburgh F., Suh J.W., Duan Y.,
RA   Shen B.;
RT   "Discovery of the Leinamycin Family of Natural Products by Mining
RT   Actinobacterial Genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 114:0-0(2017).
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. HMG-CoA synthase
CC       family. {ECO:0000256|ARBA:ARBA00007061}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PJN02062.1}.
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DR   EMBL; NNBJ01000007; PJN02062.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2M9J5I3; -.
DR   OrthoDB; 9769523at2; -.
DR   Proteomes; UP000231916; Unassembled WGS sequence.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR   GO; GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.
DR   GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR   GO; GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IEA:InterPro.
DR   CDD; cd00827; init_cond_enzymes; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR013746; HMG_CoA_synt_C_dom.
DR   InterPro; IPR013528; HMG_CoA_synth_N.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43323; 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE; 1.
DR   PANTHER; PTHR43323:SF2; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR   Pfam; PF08540; HMG_CoA_synt_C; 1.
DR   Pfam; PF01154; HMG_CoA_synt_N; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
PE   3: Inferred from homology;
FT   DOMAIN          75..177
FT                   /note="Hydroxymethylglutaryl-coenzyme A synthase N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01154"
FT   DOMAIN          274..370
FT                   /note="Hydroxymethylglutaryl-coenzyme A synthase C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08540"
SQ   SEQUENCE   418 AA;  45333 MW;  624205156F845369 CRC64;
     MNDAGDNRGS FGIEAMDVYG GSASISAQAL FAGRGLDPQR FDNVVLNRRA VALPFEDPVT
     HAVNAARPLL DRIPQRDRNR IELLVTTTES GIDYSKSVST YVHEHLGLGR NCRLLEMKQA
     CYSATGALQL AVGHLAAGIS PGAKALIIST DISLADERAQ YAEPATGTGA VALLVGDRPR
     VLAVDLGAFG LYSFETLDSA RPLPDLDIAD ADRSLLAYLE CLSHSFADYR TRVEGADFAT
     TFDQLALHTP FSGMVRAGHR RLMRELYATS PKDIQNDYER RVEPSLTYPG EVGNLFSGSL
     YLALASLIDH APLEGPARVG LFSYGSGCSS EFFSGVVGPD SAAEVGRAGI KERLANRAEL
     TFAEYTELLS HTLGCLRPVS DRTVDPAGYG RYLDRVVDRP KMLALTGVEG YHRHYEWI
//