ID A0A2M9JAL2_9ACTN Unreviewed; 2733 AA.
AC A0A2M9JAL2;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=CG740_06015 {ECO:0000313|EMBL:PJN03934.1};
OS Streptomyces sp. CB01201.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2020324 {ECO:0000313|EMBL:PJN03934.1, ECO:0000313|Proteomes:UP000231916};
RN [1] {ECO:0000313|Proteomes:UP000231916}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB01201 {ECO:0000313|Proteomes:UP000231916};
RA Pan G., Xu Z., Guo Z., Ma M., Yang D., Zhou H., Gansemans Y., Zhu X.,
RA Zhao L.-X., Jiang Y., Cheng J., van Nieuwerburgh F., Suh J.W., Duan Y.,
RA Shen B.;
RT "Discovery of the Leinamycin Family of Natural Products by Mining
RT Actinobacterial Genomes.";
RL Proc. Natl. Acad. Sci. U.S.A. 114:0-0(2017).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJN03934.1}.
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DR EMBL; NNBJ01000002; PJN03934.1; -; Genomic_DNA.
DR Proteomes; UP000231916; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR006342; FkbM_mtfrase.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR NCBIfam; TIGR01444; fkbM_fam; 1.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF05050; Methyltransf_21; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 5.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 522..596
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2642..2717
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 895..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1549..1568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2733 AA; 294187 MW; C87812FDA340B6D0 CRC64;
MFEARVRETP GEPAVEAVDH SWTYAELNAR ANRIAHWLIG RGIGPERVVA VAMPRSAEQI
AVLLGIMKAG AAYLPWDLSY PLERLAHMAA DSTPAVVLTT RLASARLPDV PGTDVVALDD
PAAVAWDEVR QSDPVDAERV APLSAAHAAY VIYTSGSTGR PKGVTVTHSG LAALRAEAVR
LGDLAVGTDA RVLQFASLSF DMSVWDLVSG LTTGAALVVP AQERLVGEDL AAFMAARGVT
HATLPPSVLA TLPPGTSRSL DRLRVLVIGG EACTPGLVTE WGPGRRFINA YGPTEATVWA
TFSGPLSEGA VPIGAAMTDT GVHLLDEHLA PVADGQAGEL YLAGPSLARG YLGHRALTAS
RFVANPLGPK GSRMYRTGDV ARRDADGQLV YLGRSDGQVK VRGQRIETGE VEAVLATHPR
VRQAVVVAQD GGAGRGRQLV GYVVPVPEEE SPGSGRGSGT GHLALELGLG PAELRAFLAK
RLPDGMVPGV VMVIDEVPLT PNGKADKAAL PRPEFRGADY RAPGSDTEKV LAGIFAEVLS
VSQVGVDDDF FTLGGDSIQS LQIASRARSR GLEVSSRQIF EFRTVSALAE AVTAHRAAPR
AVLAELDGGG AGWLPHLPAT RFLHTRGPGS ARSAQVMILE LPEGMDRAGL VATLGAVIDH
HDVLRARVVE TDGGGLLVGA PGSVSADALI RRVTQDGPWD LDATGEGAEP WHTLLRSEIG
TATSRLDPAA GVMAQFVWFD AGTARPGRLL VLLHELVVDA ESWRILVADL ASAWRRIHDG
RTPELAPVGT SVRRWAHALA DEAQRPERVA ELDLWRSIVA SPDPDLGARV LDPAAEVDAT
FTETRVDLSV EATETLLTTL RSAFRCEADD VLLAALAMAV TRWRADRGVQ ASSTLVSRES
GRTEGAVPGA DLSRTVGPLT CPTPVRLDLA GADLEEAFAG GTAAGSIVKA VKEQLRALPD
QGIGYGLLRH LNPETAAVLA RLGTGQISFR FVDRTEATAA PAQAPGLGFV PLAAVPGPGE
RGAARPALAI DASVTHTAEG PRLGALFTAP QGVLPACDVR ELADLWRQAL AALARHTAEP
GAGGPSPSDV PLVAVTQDDI DDWRQRYPGL SDIWPVPPLP AGLLVHSMMA REAGAELDTY
QVQYTLRLSG PVDPARLRTA AQALLDRHPV LRTAYAPGPD GDLVQLVVDG VDLPWQCLDL
SGLAEAMRDS TYRQFLAGDL KVHFDLDTPP MLRMALITLS EGRHDLLLTA HHANVDGWCL
PLLVRDLLQL YAAEGDASAL PPARSYREYL VWLAQQDPQE SARVWAAELA GVEEPTLIAP
EADPGADSAD VGWVGVPLPA GAARELPHRA AEVGVTLNTL VQGAWAVVLN RLSGRQDVVL
AAAVAGRPAA LPGAESIVGT FINTVPVRVP YAPDGTFAQM MTDLQERQGA LLGHHHFGLA
EIQRAAGLPA LSDSLIGFES FPLDREAIAE ASEAAGIAVT GIDLFTLSHF PVTVFVYPDG
DHLRLNLQYR QHLFSREQAH EMAELYGRVL KEIAGDPRVR LGEMARERAV EQRPHPADPD
RTAAPAAGDT QELHPAGFLR AHLGDVSEPT LMFGLRPAPG DGHRSVRRTL DAELGDRVRS
VATDLGSSPA ALFHAGWSLV VSACSGRDDV VFGTVVPGAC APYDTERAVA DILPLRVDLA
GVGVRDLLRT TDRNLRDLAH RRRTPSAVDH GHSAVPPQTP LYNAVLDYRY PDPESGDCVD
DTVAHPVTMV VDDLRHSFTL DARTDRSQDP GLVIGYLETA LTRLLDALTD RSAEQLPARE
LSVLSDTMRR EVLTEWNHTP SAAPVERTVH AWFEETAAAT PDAVAVEFED RRLSYGELNA
RANRLARHLR GLGVGPGVLV PLCLSRSEHL VVAVLAVLKA GGAYVPVDPA SPADRVAHIL
TDSAPRLLVT DGALPDGLAV PSVPVVDVTA DADRWAALAA DDVTGTGCGP SDLAYVIYTS
GSTGVPKGVM VEHRNVVRLF TSTDDWFRFD ERDVWTLFHS FAFDFSVWEI WGALLHGGRL
VVVPQAVTRN PHDFYRLLCA SGVTVLNQTP TAFRQLVAAQ AEDAEPHAVR TVVFGGEALD
VASLKPWLRR SVNKNTQLVN MYGITETTVH VTWHPLTEAD ADRPVSPIGR RIPDLCVYVL
DRHGRPAPVG AVGELYIGGA GVARGYLNRP ELTAERFLDD PFREESGARM YRSGDLARLL
PEGSLEYLGR NDDQVKIRGF RIELGEIEAR LAEHPAVQDA RVLVRTYDGE QDRRLVAYLV
PAADRAPAVR ELLRLERTEP QLLERTYELP NGLTVFQQNK SETEFLYDEI FTHLEYLRNG
ITIDDGDTVV DVGANIGLFT LFAGTRAPGA RIYAFEPIPP VFDSLRRNVD LHGLNAKVFD
CGLAAEAGEE TFTFYRHNTV ISSSVTTTEQ AHDLVRSYLR NQEELAGGGA AAEDGLVDEL
VDARLDSEQF TCRLRTLSEI ITAESIDRID LLKIDVENAE YEVLKGIQPH HWSMIRQLVV
ELHDVDGQLE KVSTLLKTLG YDLVCEQDNR LLRNTTLYNI YARRADGPSG RVPGSADTTA
PQRWAGRSAL LTDVRESLRK TLPEYMLPTA HVLLEELPLT QNGKLDQKAL PEPVSQGRAY
AAPRTPQERQ LCDLIAQVLR IDRVGMGDNF FDLGGDSLLA TRLTSRIGKT LGARVLIRAV
YEARDIAELA HTVRNAPAAN QPRLRRMNRS AQQ
//