ID   A0A2M9JEG5_9ACTN        Unreviewed;       540 AA.
AC   A0A2M9JEG5;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Acyl-CoA synthetase {ECO:0000313|EMBL:PJN05203.1};
GN   ORFNames=CG740_01760 {ECO:0000313|EMBL:PJN05203.1};
OS   Streptomyces sp. CB01201.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2020324 {ECO:0000313|EMBL:PJN05203.1, ECO:0000313|Proteomes:UP000231916};
RN   [1] {ECO:0000313|Proteomes:UP000231916}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB01201 {ECO:0000313|Proteomes:UP000231916};
RA   Pan G., Xu Z., Guo Z., Ma M., Yang D., Zhou H., Gansemans Y., Zhu X.,
RA   Zhao L.-X., Jiang Y., Cheng J., van Nieuwerburgh F., Suh J.W., Duan Y.,
RA   Shen B.;
RT   "Discovery of the Leinamycin Family of Natural Products by Mining
RT   Actinobacterial Genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 114:0-0(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PJN05203.1}.
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DR   EMBL; NNBJ01000001; PJN05203.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2M9JEG5; -.
DR   OrthoDB; 3443462at2; -.
DR   Proteomes; UP000231916; Unassembled WGS sequence.
DR   GO; GO:0016877; F:ligase activity, forming carbon-sulfur bonds; IEA:UniProt.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43767; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR   PANTHER; PTHR43767:SF1; NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
FT   DOMAIN          10..394
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          448..524
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   540 AA;  58337 MW;  7FEE91ECA7CC9FC6 CRC64;
     MEYNLADLFE SVVDVVPDRE ALVYIDHPGT GAERRLTYRQ LDEGANRLAH HLIDAGLKPG
     EHLGLHLYNG IEYLQTVLAA LKARLVPVNV NYRYVEEELV YLYRDADLAA LVFDAEFTER
     VAGALPRTER LRHLVRVGAA PDGAPALVAT AFTEAEAAGS PSRGFAARSA DDQFIIYTGG
     TTGMPKGVMW RQEDLFFAGL FGGEPAGEPV KRPEELAERV AKSGSGLTFF PAPPLMHGTS
     TLTSFVAFNY GQRVVIHRKY VPEEVLRTIE KERVTSVSLV GDAMLRPLVD ALHGPLKGTD
     MSSLFSVSSS GAIMSDTVRA QLQALVPNAL ILNNFGSSES GSNGKATDDS GPEKGFRLEV
     NERTQVVDPA SYEPVAIGEV GRLAQRGHVP LGYYNDPAKT AETFFQKGAE RWVLLGDMAT
     VDEDGIVTVL GRGSQCINTG GEKVYPEEVE QALKAHPDVY DALVAGVPDA KWGSHVAAVV
     QVRDGAAEPT LEGIQAHCRT RLAGYKVPRQ LVITPGIQRS PSGKADYRWA RSVAAEADGT
//