ID A0A2M9JGB8_9ACTN Unreviewed; 714 AA.
AC A0A2M9JGB8;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=aminodeoxychorismate synthase {ECO:0000256|ARBA:ARBA00013139};
DE EC=2.6.1.85 {ECO:0000256|ARBA:ARBA00013139};
GN Name=pabB {ECO:0000313|EMBL:PJN05931.1};
GN ORFNames=CG723_42140 {ECO:0000313|EMBL:PJN05931.1};
OS Streptomyces sp. CB01635.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2020326 {ECO:0000313|EMBL:PJN05931.1, ECO:0000313|Proteomes:UP000232157};
RN [1] {ECO:0000313|Proteomes:UP000232157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB01635 {ECO:0000313|Proteomes:UP000232157};
RA Pan G., Xu Z., Guo Z., Ma M., Yang D., Zhou H., Gansemans Y., Zhu X.,
RA Zhao L.-X., Jiang Y., Cheng J., van Nieuwerburgh F., Suh J.W., Duan Y.,
RA Shen B.;
RT "Discovery of the Leinamycin Family of Natural Products by Mining
RT Actinobacterial Genomes.";
RL Proc. Natl. Acad. Sci. U.S.A. 114:0-0(2017).
CC -!- SIMILARITY: In the C-terminal section; belongs to the anthranilate
CC synthase component I family. {ECO:0000256|ARBA:ARBA00005970}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJN05931.1}.
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DR EMBL; NNBL01000038; PJN05931.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2M9JGB8; -.
DR OrthoDB; 3518032at2; -.
DR Proteomes; UP000232157; Unassembled WGS sequence.
DR GO; GO:0046820; F:4-amino-4-deoxychorismate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd01743; GATase1_Anthranilate_Synthase; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005802; ADC_synth_comp_1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR006805; Anth_synth_I_N.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR017926; GATASE.
DR InterPro; IPR006221; TrpG/PapA_dom.
DR NCBIfam; TIGR00553; pabB; 1.
DR NCBIfam; TIGR00566; trpG_papA; 1.
DR PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR PANTHER; PTHR11236:SF18; AMINODEOXYCHORISMATE SYNTHASE; 1.
DR Pfam; PF04715; Anth_synt_I_N; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR Pfam; PF00117; GATase; 1.
DR PRINTS; PR00097; ANTSNTHASEII.
DR PRINTS; PR00099; CPSGATASE.
DR PRINTS; PR00096; GATASE.
DR SUPFAM; SSF56322; ADC synthase; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 3: Inferred from homology;
KW Glutamine amidotransferase {ECO:0000256|PROSITE-ProRule:PRU00605};
KW Reference proteome {ECO:0000313|Proteomes:UP000232157};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 7..189
FT /note="Glutamine amidotransferase"
FT /evidence="ECO:0000259|Pfam:PF00117"
FT DOMAIN 249..377
FT /note="Anthranilate synthase component I N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04715"
FT DOMAIN 432..686
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
FT ACT_SITE 86
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 173
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 175
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 714 AA; 77376 MW; 2B7DB2B6B8B074D7 CRC64;
MRTVRTLLID NYDSFTYNLF QMLAEVNAEV PVVIKNDDHA AWAALDPADF DNVVVSPGPG
HPGTDTDLGL SRRVIEEWDL PLLGVCLGHQ ALCLLGGGEV GHAPEPVHGR TSRIEHDGRE
LFAEIPSPLR VVRYHSLTVH ELPAELESTA STRDGLLMAV RHRGAPRWGV QFHPESVSSE
YGHRLLANFR DLSLRALGRA PLGVEVPGVA GDDTRQDRPG GPGDLRLHVR ELAEAPDADA
AFEELFGDAP ARFWLDSSRV DPGLSRFTFL GAPQGPLGEI LTYDVAERLV RVRDRSGDEV
LRRPGTLFAH LERELAARST PAPELPFEFN LGYVGYLGYE TKADSGGDRT HTAELPDGAF
VFADRMVAVD HADGRAWLLA LSSDRHPASA RDADDWLADA ARALAGTVPR PPFRLLPDEE
LLPLDVEFRH DAAEYRELVE ECRSLIRDGE TYEVCLTNLL RVPGRVDPLT AYRALRAISP
APYAAYLQFP EGAVLSSSPE RYLRIDAAGT AESKPIKGTR PRGATPAEDE ALARGLAAAE
KDRSENLMIV DLVRNDLGQV CEIGSVHVPK LFDVESYATV HQLVSTVRGR LAADVSRPEA
VRAAFPGGSM TGAPKVRTMQ FIDRLEGGPR GVYSGALGYF ALSGAVDLSI VIRTIVATAD
AATIGVGGAV IALSDPDDEV QEMLLKARTT LRALRQAQAV APAGKRELLA GSVR
//
