ID A0A2M9JID5_9ACTN Unreviewed; 360 AA.
AC A0A2M9JID5;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=Serine protease {ECO:0000313|EMBL:PJN06628.1};
GN ORFNames=CG723_37725 {ECO:0000313|EMBL:PJN06628.1};
OS Streptomyces sp. CB01635.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2020326 {ECO:0000313|EMBL:PJN06628.1, ECO:0000313|Proteomes:UP000232157};
RN [1] {ECO:0000313|Proteomes:UP000232157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB01635 {ECO:0000313|Proteomes:UP000232157};
RA Pan G., Xu Z., Guo Z., Ma M., Yang D., Zhou H., Gansemans Y., Zhu X.,
RA Zhao L.-X., Jiang Y., Cheng J., van Nieuwerburgh F., Suh J.W., Duan Y.,
RA Shen B.;
RT "Discovery of the Leinamycin Family of Natural Products by Mining
RT Actinobacterial Genomes.";
RL Proc. Natl. Acad. Sci. U.S.A. 114:0-0(2017).
CC -!- SIMILARITY: Belongs to the peptidase S1 family.
CC {ECO:0000256|ARBA:ARBA00007664}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJN06628.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NNBL01000027; PJN06628.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2M9JID5; -.
DR OrthoDB; 8781117at2; -.
DR Proteomes; UP000232157; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd21112; alphaLP-like; 1.
DR Gene3D; 3.30.300.50; -; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR004236; Pept_S1_alpha_lytic.
DR InterPro; IPR001316; Pept_S1A_streptogrisin.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR035070; Streptogrisin_prodomain.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR Pfam; PF02983; Pro_Al_protease; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PIRSF; PIRSF001134; Streptogrisin; 1.
DR PRINTS; PR00861; ALYTICPTASE.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001134-2};
KW Hydrolase {ECO:0000313|EMBL:PJN06628.1};
KW Protease {ECO:0000313|EMBL:PJN06628.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000232157};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..360
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014876958"
FT DOMAIN 102..156
FT /note="Peptidase S1A alpha-lytic prodomain"
FT /evidence="ECO:0000259|Pfam:PF02983"
FT DOMAIN 200..351
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|Pfam:PF00089"
FT ACT_SITE 206
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR001134-1"
FT ACT_SITE 234
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR001134-1"
FT ACT_SITE 316
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR001134-1"
FT DISULFID 187..207
FT /evidence="ECO:0000256|PIRSR:PIRSR001134-2"
FT DISULFID 310..337
FT /evidence="ECO:0000256|PIRSR:PIRSR001134-2"
SQ SEQUENCE 360 AA; 36610 MW; B9C071F529143749 CRC64;
MKHRRIPKRR AAAVGAGIAA LVAAGVTFQT ANASTDTPDV APQTLSIAKA GNLASSLTKD
LGADSAGTYY DAKAKHLVVN VLNKDAADVV RAAGAKARVV ENSLAELKGA RTTLKQDATI
PGTSWAVDPA TNKVVVTADR TVDTAAWSKL SKVVDGLGSK AELQRTKGEF KPLIAGGDAI
TGSGGRCSLG FNVVKGGQPY FITAGHCTEA ISTWSDSSGQ EIGTNEQSSF PDNDFGLVKY
TADVAHPSEV DLYNGSSQQI TKAGDATVGM KVTRSGSTTQ VHDGSVTGLD ATVNYGNGDI
VNGLIQTDVC AEPGDSGGSL FSGDTAIGLT SGGSGDCSSG GETFFQPVTE ALSTFGAEIG
//
