ID   A0A2M9JK58_9ACTN        Unreviewed;       590 AA.
AC   A0A2M9JK58;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN   ORFNames=CG723_35295 {ECO:0000313|EMBL:PJN07255.1};
OS   Streptomyces sp. CB01635.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2020326 {ECO:0000313|EMBL:PJN07255.1, ECO:0000313|Proteomes:UP000232157};
RN   [1] {ECO:0000313|Proteomes:UP000232157}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB01635 {ECO:0000313|Proteomes:UP000232157};
RA   Pan G., Xu Z., Guo Z., Ma M., Yang D., Zhou H., Gansemans Y., Zhu X.,
RA   Zhao L.-X., Jiang Y., Cheng J., van Nieuwerburgh F., Suh J.W., Duan Y.,
RA   Shen B.;
RT   "Discovery of the Leinamycin Family of Natural Products by Mining
RT   Actinobacterial Genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 114:0-0(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PJN07255.1}.
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DR   EMBL; NNBL01000022; PJN07255.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2M9JK58; -.
DR   OrthoDB; 5621159at2; -.
DR   Proteomes; UP000232157; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF13531; SBP_bac_11; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000232157};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        26..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          386..583
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          210..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          336..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..258
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   590 AA;  61899 MW;  0FB494BCF9AFABC3 CRC64;
     MGRHSLPDEY GTDAVGPRPR TRGRTVAIAT ALVLVVAGGT ALAARSGLLS FGGACDGKTV
     HLDIAASPDV APALRDAADL ARKKHLTSDG QCLDTRVQAG DSYKIADSLR KGGKGAGGYE
     AWVPDSSLWI RRAGLGGNAT PVTAMGNIAS SPIGISMVPS AAKSMGWPAK QYTWAQLTGA
     AMEGDKLRLG TADPARSATG LLALTQLGAS TKKSGSEGDT QAAAMAKALS QRTTDSDGQL
     TDTLARDSSG TEQGNPRRNQ ALFLSEQSSF RYNATAGDKD GLDLFYPKDG SPQLDYPFAL
     VDEGDKSTDE RRAAIRFMTL LGEDAGIRIL DRHGFRTDDE EPSDAVVAGA GGRTPQPYAT
     SDSEPPTDKE LQETLGMWTI TVQSARITVV VDASASMANY VPGRNQSRME VTKASMLQAL
     ATFTPEDEIG LWEFATLLDG NRDYRRLVPT ERLGDRKGGG TQRDRLSEAF SGLQPVPGGA
     TGLYDTTLAA YEEATSSYRS GKFNALVVVT DGANQDLGSI SRSHLVSRLR SLADPQHPVP
     LIAIAVGPDA DKDEVEQIAG ATGGSGHQVS DPAQIHAVIL KAIVEAGAKG
//