ID A0A2M9JQ14_9ACTN Unreviewed; 532 AA.
AC A0A2M9JQ14;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Na+/H+ antiporter {ECO:0000313|EMBL:PJN08964.1};
GN ORFNames=CG723_26135 {ECO:0000313|EMBL:PJN08964.1};
OS Streptomyces sp. CB01635.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2020326 {ECO:0000313|EMBL:PJN08964.1, ECO:0000313|Proteomes:UP000232157};
RN [1] {ECO:0000313|Proteomes:UP000232157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB01635 {ECO:0000313|Proteomes:UP000232157};
RA Pan G., Xu Z., Guo Z., Ma M., Yang D., Zhou H., Gansemans Y., Zhu X.,
RA Zhao L.-X., Jiang Y., Cheng J., van Nieuwerburgh F., Suh J.W., Duan Y.,
RA Shen B.;
RT "Discovery of the Leinamycin Family of Natural Products by Mining
RT Actinobacterial Genomes.";
RL Proc. Natl. Acad. Sci. U.S.A. 114:0-0(2017).
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000256|RuleBase:RU366002}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU366002};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU366002}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU366002}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU366002}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJN08964.1}.
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DR EMBL; NNBL01000011; PJN08964.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2M9JQ14; -.
DR OrthoDB; 57886at2; -.
DR Proteomes; UP000232157; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR NCBIfam; TIGR00831; a_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU366002};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU366002};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU366002};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366002};
KW Reference proteome {ECO:0000313|Proteomes:UP000232157};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU366002};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU366002};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366002}.
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 108..132
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 221..245
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 266..287
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 299..323
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 344..367
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 379..402
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT DOMAIN 8..403
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
SQ SEQUENCE 532 AA; 58034 MW; 4973D47D29A733F9 CRC64;
MDVLPLVALI AASAAVAGAA RRTPVPAPLL LVAVGLVASY LPGVPHYTLD PHIVLPLILP
PLLHTAALES SYLDLRANIR PVALLSVGYV LFATVSVGWL AYELIPDLPL TAALVLGAVI
APPDAVAATA IARKVGLPAR ITTILQGESL VNDATAITAY KVALAAAVGE GASWAGGIRE
FLVASVGGVG VGLVLMVPLH WLRRHLKEAI LQNTLSLLIP FVAYAAAEQV GASGVLAVVT
VALYLGHHAW QVDFETRLQE AAVWKVVAFI LESAVFALIG LQLPFVLKDL GEYSVGEALG
YAVAVFVLVV VMRFVWSYPA TYLPWWLSAR IRERERDTDW RRPLVVSWAG MRGVVSLAIA
FSIPLFVDDG SRFPARNLVL FLTFTTVIGT LVVQGLSLPW LIKILKLPGR DTQAETLAEA
QAQNAASQAA EERVNELMED ERNCLPEPLE DRLRTVLERR RNSVWERLGH ANPVTGESAD
DTYRRLTREA IAAEREVFVR MRDERRIDDE MMRTLLRKLD LEEAAAYREV DD
//
