ID A0A2M9R4I4_9FLAO Unreviewed; 1115 AA.
AC A0A2M9R4I4;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969,
GN ECO:0000313|EMBL:PJR03769.1};
GN ORFNames=CDL10_03950 {ECO:0000313|EMBL:PJR03769.1};
OS Avrilella dinanensis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Avrilella.
OX NCBI_TaxID=2008672 {ECO:0000313|EMBL:PJR03769.1, ECO:0000313|Proteomes:UP000231960};
RN [1] {ECO:0000313|EMBL:PJR03769.1, ECO:0000313|Proteomes:UP000231960}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UR159 {ECO:0000313|EMBL:PJR03769.1,
RC ECO:0000313|Proteomes:UP000231960};
RA Leyer C., Sassi M., Minet J., Kayal S., Cattoir V.;
RT "Description of Avrilella dinanensis gen. nov. sp. nov.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJR03769.1}.
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DR EMBL; NIPO01000001; PJR03769.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2M9R4I4; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000231960; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000231960}.
FT DOMAIN 571..732
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 753..907
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1115 AA; 128207 MW; CE726CF62D427516 CRC64;
MNLSDIYANN SKTKQLLKSI LVKRNQILAK GFVGSSLSFV VQELFRQADN PFMLVFNDKE
EAAYYLNDLE NLLNKKDVLF YPGSYRRPYE IETTDNANVL LRAEVLNRIN SRKKPAIIVT
YADALLEKVV TKKQLEQNTL RLILNEEISL DKVNETLFEY DFKRVDFVTE PGEFSVRGGI
LDVFSFSNDL PYRIEFFGDE IDSIRTFDIE TQLSVENLKK IDIIPNIANK STQEQRENFL
SFIKNETIVF VQNTQFLKDR LQHLFEKAED AFARLDQTIK RLSPAEMFVS GKELTKQLFH
FTSVCLNENP DFVPNEKIEF LFRPQPTFNK QFDLLIDNLN TNHQNGYVNY LYCTSEAQAT
RFYDIFENFK ENGQKQVISY ETKVFPLYQG FIDDENQIAC YTDHQIFERY HRFSIKNSKN
KKQNITLKEL TSLSVGDYVT HIDHGIGKFG GLQKIEVDGK KQEAIKLIYA DNDIVYVGIH
ALHKIAKYNG KDGAEPKIYK LGSQAWKNLK KKTKARVKEI AFNLIKLYAK RRTERGFACA
PDSYLQAELE SSFLYEDTPD QYKATNDVKA DMENERPMDR LVCGDVGFGK TEVAIRAAFK
MVDNGKQVAV LVPTTVLAFQ HYQTFRERLK NLPIRVEYLN RFKTGKQKTQ TLEDLANGKI
DIIIGTHQLV GKSIQFKDLG LLIVDEEQKF GVAVKDKLKT LGENIDTLTL TATPIPRTLQ
FSLMAARDLS IISTPPPNRY PIETSVVGFN EETIRDAISM ELERGGQVFF INNRIENIRE
IAGMIQRLVP DARVAVGHGQ MDGKQLERTL LDFIDGKYDV LVATTIIESG LDVPNANTIF
INNANNFGLS DLHQMRGRVG RSNKKAFCYF ICPPYSLMTE EARKRLEALE QFSDLGSGFN
IAMKDLEIRG AGDLLGGEQS GFINEIGFET YQKIMNEAIE ELKEDEFKEL YDENEPEKPK
KYVRDFVLES DFEVLFPDDY VNNITERMNL YNELNAVKNE QELAKFEEKI TDIFGQIPPT
ARNLLDSVKI KWKAVELGIE KLVLKQGKMI GYFVADQSSP FYQTDQFRKV LMFVQNNPTL
CRLKEKETKK GLRLLLTFEQ VKSIDKALSL IYKIN
//
