ID   A0A2M9R892_9FLAO        Unreviewed;       733 AA.
AC   A0A2M9R892;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=RelA/SpoT family protein {ECO:0000313|EMBL:PJR05072.1};
GN   ORFNames=CDL10_04100 {ECO:0000313|EMBL:PJR05072.1};
OS   Avrilella dinanensis.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Avrilella.
OX   NCBI_TaxID=2008672 {ECO:0000313|EMBL:PJR05072.1, ECO:0000313|Proteomes:UP000231960};
RN   [1] {ECO:0000313|EMBL:PJR05072.1, ECO:0000313|Proteomes:UP000231960}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UR159 {ECO:0000313|EMBL:PJR05072.1,
RC   ECO:0000313|Proteomes:UP000231960};
RA   Leyer C., Sassi M., Minet J., Kayal S., Cattoir V.;
RT   "Description of Avrilella dinanensis gen. nov. sp. nov.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC       is a mediator of the stringent response that coordinates a variety of
CC       cellular activities in response to changes in nutritional abundance.
CC       {ECO:0000256|RuleBase:RU003847}.
CC   -!- SIMILARITY: Belongs to the relA/spoT family.
CC       {ECO:0000256|RuleBase:RU003847}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PJR05072.1}.
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DR   EMBL; NIPO01000001; PJR05072.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2M9R892; -.
DR   OrthoDB; 9805041at2; -.
DR   Proteomes; UP000231960; Unassembled WGS sequence.
DR   GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR   CDD; cd04876; ACT_RelA-SpoT; 1.
DR   CDD; cd00077; HDc; 1.
DR   CDD; cd05399; NT_Rel-Spo_like; 1.
DR   CDD; cd01668; TGS_RSH; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   Gene3D; 3.30.70.260; -; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR004811; RelA/Spo_fam.
DR   InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR   InterPro; IPR007685; RelA_SpoT.
DR   InterPro; IPR004095; TGS.
DR   InterPro; IPR012676; TGS-like.
DR   InterPro; IPR033655; TGS_RelA/SpoT.
DR   NCBIfam; TIGR00691; spoT_relA; 1.
DR   PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR   PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR   Pfam; PF13291; ACT_4; 1.
DR   Pfam; PF13328; HD_4; 1.
DR   Pfam; PF19296; RelA_AH_RIS; 1.
DR   Pfam; PF04607; RelA_SpoT; 1.
DR   Pfam; PF02824; TGS; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00954; RelA_SpoT; 1.
DR   SUPFAM; SSF55021; ACT-like; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   SUPFAM; SSF81271; TGS-like; 1.
DR   PROSITE; PS51880; TGS; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000231960}.
FT   DOMAIN          402..463
FT                   /note="TGS"
FT                   /evidence="ECO:0000259|PROSITE:PS51880"
SQ   SEQUENCE   733 AA;  83604 MW;  4253F1279B5A1B9C CRC64;
     MTTEDIEKEN KAIAQEYKEL LRISYQTLND DEKKLIRKAF DVAVEAHKDQ RRKSGEAYIF
     HPIAVAKIVA SEIGLGATSI ASALLHDVVE DTDITVEQIE EMFNPKIAQI VAGLTKISRM
     EPDPDISLQA ENYRKMLLTL HDDVRVILIK IADRLHNMQT MEGMVPYKQA KIASETLYIY
     APLAHRLGLF NIKIKLEDLG LKYTEPEVYQ DILSKIKESK EEQDAYIKLI SDVLSESLDK
     ENIKYSIKGR SKSIYSIYRK MKMQGVTFDE VYDKFALRIV YESEQQNEKF LAWKIYSVVT
     DHYRPSPNRL RDWISSPKST GYEALHITVM GPKGRWVEVQ VRSERMDEIA EKGYAAHYKY
     KQGVSEENSL DIWLNHLREA LENSSENAVD FVEDFKLNFY AKEIYVFTPK GEIKSLPKGA
     TALDFAFSVH SEVGIKTRGA KVNGKLVPLN YVLNSGDQVE IITSSNQKPS VHWLEFVSTA
     RARNKIKNVL NEDIKSRAEE GKEILQRKLK HLKIDWSEKT VNDLVNYFKE KTSQDVFYKA
     GTGAIDNQQL KEFANHKNSN TFFNLFRKSI RKTEPPVKTD SNLDLIVFGD GEEKLDYKLA
     NCCNPIPGDD VFGFVTINEG IKVHKKNCPN AISLRSNYAY RIMSAKWIDS TNQEFDVTLK
     IFGIDELGLT NELTKVISNN MAINIRSISL SSDAGIFTGE IKVSVPNNHV LQKLINNIKS
     VNGVEKVTRM QTS
//