ID A0A2N0ESG0_9FLAO Unreviewed; 768 AA.
AC A0A2N0ESG0;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=ATE92_1169 {ECO:0000313|EMBL:PKA83023.1};
OS Ulvibacter sp. MAR_2010_11.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Ulvibacter.
OX NCBI_TaxID=1250229 {ECO:0000313|EMBL:PKA83023.1, ECO:0000313|Proteomes:UP000232889};
RN [1] {ECO:0000313|EMBL:PKA83023.1, ECO:0000313|Proteomes:UP000232889}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mar_2010_11 {ECO:0000313|EMBL:PKA83023.1,
RC ECO:0000313|Proteomes:UP000232889};
RA Teeling H.;
RT "A large-scale integrated study on North Sea by COGITO (Coastal Microbe
RT Genomic & Taxonomic Observatory).";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKA83023.1}.
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DR EMBL; PHTY01000001; PKA83023.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N0ESG0; -.
DR Proteomes; UP000232889; Unassembled WGS sequence.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR011815; PBP_1c.
DR InterPro; IPR009647; PBP_C.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02073; PBP_1c; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF15; PENICILLIN-BINDING PROTEIN 1C; 1.
DR Pfam; PF06832; BiPBP_C; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670}.
FT DOMAIN 42..203
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 283..539
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 672..760
FT /note="Penicillin-binding C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06832"
SQ SEQUENCE 768 AA; 86221 MW; CED8B8F776CB2214 CRC64;
MFAGFGFWLF CLPAPLFDVS SATVVESSEG TMLGARIADD GQWRFPKMDS VPYRFEQSVI
YFEDEYFYQH PGFNPVSMSK ALWNNLTTDS RRGGSTLTQQ VIRLSRENKQ RSYAEKLIEI
VQSTRLEAGK SKKEILNLYA SYAPFGGNVV GLETASWRYF GIPATELSWG QSAALAVLPN
APSLIFPGKN EAIFLEKRNR LLLKLFQKEI IDKTTYELAV AENLPGKPYP LPEIAPHFTE
KLRREHSGKR IQTTLSYALQ QKINTITKEH HYVLAQNQIH NLAVLILDVN TREVLAYVGN
APTTRENNNF VDIIDKSRST GSILKPFLFA AMLDSGELLP NTLVADIPTT VNGYSPENFD
KQFNGAVPAS LALSRSLNVP AVRMLREYGL DRFYKRLQEL NFKGITKPAD YYGLSLILGG
AESSLWDITN AYAGMASTLQ YFNGSSSEYR TQEFSNPVYI KGAQAKFGEI QSKPPVFNAG
SIFETLNSLQ EVNRPEGEVN WNFFSNSQPL AWKTGTSFGF KDAWAVGVTS EYAIGVWVGN
ADGEGRPGLT GIQAAAPVLF DVLDVLPRND WFAIPYDELI ETEICAKSGH LAGVYCDKTL
LEWIPKVGSR TTPCSYHQRV FLTSSEMYQV NSSCYPLAQM QQKNWFTLPP IMEYYYASLH
PEYKVLPPYA EGCLQAGERK MDFIFPKKNE AILLPKNFDE NVNEVIFKLA HRSPETIVYW
YLDTQFIGST QTFHELALAP KPGKYLLSAT DQEGNEVSQK IEITAASM
//
