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Database: UniProt
Entry: A0A2N0FT82_9FLAO
LinkDB: A0A2N0FT82_9FLAO
Original site: A0A2N0FT82_9FLAO 
ID   A0A2N0FT82_9FLAO        Unreviewed;       192 AA.
AC   A0A2N0FT82;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=precorrin-2 dehydrogenase {ECO:0000256|ARBA:ARBA00012400};
DE            EC=1.3.1.76 {ECO:0000256|ARBA:ARBA00012400};
GN   ORFNames=B0O79_1302 {ECO:0000313|EMBL:PKA97634.1};
OS   Flavobacteriaceae bacterium MAR_2009_75.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae.
OX   NCBI_TaxID=1250285 {ECO:0000313|EMBL:PKA97634.1, ECO:0000313|Proteomes:UP000232536};
RN   [1] {ECO:0000313|EMBL:PKA97634.1, ECO:0000313|Proteomes:UP000232536}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mar_2009_75 {ECO:0000313|EMBL:PKA97634.1,
RC   ECO:0000313|Proteomes:UP000232536};
RA   Teeling H.;
RT   "A large-scale integrated study on North Sea by COGITO (Coastal Microbe
RT   Genomic & Taxonomic Observatory).";
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin;
CC         Xref=Rhea:RHEA:15613, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58351, ChEBI:CHEBI:58827; EC=1.3.1.76;
CC         Evidence={ECO:0000256|ARBA:ARBA00001156};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
CC       biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00005010}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PKA97634.1}.
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DR   EMBL; PHTZ01000001; PKA97634.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2N0FT82; -.
DR   OrthoDB; 45564at2; -.
DR   UniPathway; UPA00262; UER00222.
DR   Proteomes; UP000232536; Unassembled WGS sequence.
DR   GO; GO:0004325; F:ferrochelatase activity; IEA:InterPro.
DR   GO; GO:0043115; F:precorrin-2 dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019354; P:siroheme biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR028161; Met8.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR028281; Sirohaem_synthase_central.
DR   InterPro; IPR006367; Sirohaem_synthase_N.
DR   NCBIfam; TIGR01470; cysG_Nterm; 1.
DR   PANTHER; PTHR35330; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR   PANTHER; PTHR35330:SF1; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR   Pfam; PF13241; NAD_binding_7; 1.
DR   Pfam; PF14824; Sirohm_synth_M; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF75615; Siroheme synthase middle domains-like; 1.
PE   4: Predicted;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244}.
FT   DOMAIN          125..149
FT                   /note="Siroheme synthase central"
FT                   /evidence="ECO:0000259|Pfam:PF14824"
SQ   SEQUENCE   192 AA;  21755 MW;  B1C0B817FC5A92AA CRC64;
     MERNELYPVF LKVSELKVLI VGGGNVALEK LTFLLKSSPN AKVDMVAPMY REDTIALANE
     YDIVMHRASY DSSYLDKKHI VIATTDRSEV NELVYNDCRT RSILVNVADN PPLCDFYMGG
     IVTKGNVKIA ISTNGKSPTT AKRLRQFFED VIPENIDDLV KNLNEYRKTI KGDFEQKVET
     LNEFTKGLVQ KK
//
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