ID A0A2N1GBV7_9FLAO Unreviewed; 1057 AA.
AC A0A2N1GBV7;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Hydrophobe/amphiphile efflux-1 family RND transporter {ECO:0000313|EMBL:PKH69094.1};
GN ORFNames=CXF59_02205 {ECO:0000313|EMBL:PKH69094.1};
OS Flavobacterium sp. ALD4.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=2058314 {ECO:0000313|EMBL:PKH69094.1, ECO:0000313|Proteomes:UP000233842};
RN [1] {ECO:0000313|EMBL:PKH69094.1, ECO:0000313|Proteomes:UP000233842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ALD4 {ECO:0000313|EMBL:PKH69094.1,
RC ECO:0000313|Proteomes:UP000233842};
RA Collins E., Ducluzeau A.-L.;
RT "Pharmacopeia of the Arctic Ocean.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKH69094.1}.
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DR EMBL; PJBJ01000022; PKH69094.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N1GBV7; -.
DR OrthoDB; 9758940at2; -.
DR Proteomes; UP000233842; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF9; SIMILAR TO MULTIDRUG RESISTANCE PROTEIN MEXB; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233842};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..561
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 872..888
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 895..919
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 925..950
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 971..990
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1002..1028
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1057 AA; 115623 MW; 48BD7058F6B5F711 CRC64;
MFNKFIQRPV LSIVISLIIV FLGVISVMNL PITQFPSISP PMVNVTADYP GSNGELMIKS
VIIPLERALN GVPGMKYMTS DAGNDGEASI QVVFNLGTDP NQAAINVQNR VASVVNKLPP
LVVREGVKIT REVPSMLMYV NLFSTDKGTD QKFLYNYADI NVLSELKRVN GVGSGDILGT
REYAMRIWLK PDRMLAYKIS TDEVMEALSS QSLEASPGKT GEASGKRSQA FEYVLKYSGR
FTTEKQYGNI VLRSNANGEI LRLKDVANIE FGSSMYDIYS NLNGKPSAAI VLKQSFGSNA
NQVIEDVKAK LETIKKKFPK GMDYEISYDV SKFLDASIEK VIHTLIEAFI LVGLVVFLFL
GDWRSTIIPA IAVPVSLVGT FMFMQFFDIS LNLITLFALV LAIGVVVDDA IVVIEAVHAK
MEEEHLSALK ATKKAMHEIS GAIVAITFLM AAVFIPVAFM SGPVGVFYRQ FSITMATAII
LSGIVALTLT PALCAMMLKN NHGQPKKKTP INRFVDGFNN TFNLAQGKYQ NLLGKIINRR
AITFIALVGF CAGTWLISIT VPSGFIPNED QGMFYAIIQT PPGSSLERTN DISVKLQKIA
EGVEGVKSVS SLAGYEILTE GTGSNAGTCL INLKDWDDRK HSVVEIMAEL EEKSKDIPGA
NIEFFQPPAV PGYGAAGGFE LRLLDKTGSG DYKKMEVINN DFVKELNKRK ELSNVFSFFS
ASFPQYMMKV DNDLAQQKGI SIENAMNTLS TLVGSNYEIS FIKYGINYKV IVQASPEYRA
LPEDILKLYV KNDRDEMVPY SAFMKLEKVY GLSEITRHNM YTSTEISGSA ASGYSSGTAI
KVIQEVAAEK LPRGYDIDWA GISADEVSQG NQAIWVFLIC LGFVYLVLAA QYESFILPLS
VILSLPAGIF GAFLLLKLTG LENNIYAQVA MVMLIGLLGK NAVLIVEFAI QRHAAGKSVL
EAAMEGAKAR FRPILMTSFA FIAGLLPLVF ATGPGKIGNR TIGTAAAGGM LIGTICGVFV
IPGLYYIFGR IAEKYKLVKK EEENPLTEEI DNNEVHK
//
