ID   A0A2N1J818_9BASI        Unreviewed;       788 AA.
AC   A0A2N1J818;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Alpha/beta hydrolase fold-3 domain-containing protein {ECO:0000259|Pfam:PF07859};
GN   ORFNames=MVES_003383 {ECO:0000313|EMBL:PKI82683.1};
OS   Malassezia vespertilionis.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX   NCBI_TaxID=2020962 {ECO:0000313|EMBL:PKI82683.1, ECO:0000313|Proteomes:UP000232875};
RN   [1] {ECO:0000313|EMBL:PKI82683.1, ECO:0000313|Proteomes:UP000232875}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NWHC:44797-103 {ECO:0000313|EMBL:PKI82683.1,
RC   ECO:0000313|Proteomes:UP000232875};
RA   Lorch J.M., Palmer J.M., Vanderwolf K.J., Schmidt K.Z., Verant M.L.,
RA   Weller T.J., Blehert D.S.;
RT   "A novel species of cold-tolerant Malassezia isolated from bats.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a diacylglycerol + H2O = a fatty acid + a monoacylglycerol +
CC         H(+); Xref=Rhea:RHEA:32731, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17408, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868;
CC         Evidence={ECO:0000256|ARBA:ARBA00043665};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a monoacylglycerol + H2O = a fatty acid + glycerol + H(+);
CC         Xref=Rhea:RHEA:15245, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17408, ChEBI:CHEBI:17754, ChEBI:CHEBI:28868;
CC         Evidence={ECO:0000256|ARBA:ARBA00043831};
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DR   EMBL; KZ454994; PKI82683.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2N1J818; -.
DR   STRING; 2020962.A0A2N1J818; -.
DR   OrthoDB; 1943592at2759; -.
DR   Proteomes; UP000232875; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013094; AB_hydrolase_3.
DR   InterPro; IPR002168; Lipase_GDXG_HIS_AS.
DR   PANTHER; PTHR48081; AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C; 1.
DR   PANTHER; PTHR48081:SF5; ABHYDROLASE_3 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF07859; Abhydrolase_3; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   PROSITE; PS01173; LIPASE_GDXG_HIS; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000232875}.
FT   DOMAIN          202..328
FT                   /note="Alpha/beta hydrolase fold-3"
FT                   /evidence="ECO:0000259|Pfam:PF07859"
FT   REGION          149..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          672..691
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          740..765
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..182
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        749..764
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   788 AA;  88927 MW;  162515DF7896E366 CRC64;
     MTVSTLGILA HVTPALIKNA FRNYVRFWIT LGDGSKRLSA NEFYYNQVFL MIKELADYLT
     HETAEDVQKL TDTQLPAPPW ASSRKVMIPM STCSDAAQYL IEYFGPQSLQ EVVGGARWWQ
     MRTLEGVPGE WISQYTDYHT VVRASEGKNT SLSTSMAKHM TRNTQNRNPR HEQPNQPYEQ
     PNSEAGRYAD TDEERTRLTR VMLYFHGGGY YFGSNETHRF MILRIARKFG GFAFAVNYRK
     APQYPFPCAI QDCLAAYLYL TRPPPGAKHA PVPPESIVFG GDSAGGGLAL AVLQVLRDLE
     LPLPAGAVLL SPWCDLTHSF PSILQNTKTD YIPPYSFIHK PSAMWPLPTD TGVFAHSWCM
     FGKRRSRSVP PPAACKQEEV VNVTDPTGKS IPVTSQVQMY ATNAQLFHPL CSPALSGSLG
     GLPPLFVLAG DAEVLRDEAI YIAHKAAHPD RFPLRDELMD RYPSMRKMQA KYYHQPTKVH
     LQVYDAQCHV FPMFLLTTPA KYAFRALTSF IKYVTGAPCM EVPQASGAQK EWQYSGTDGD
     AFFQPNEESV YSGKVPLHRH AFDGNMIRER VDYTGKVRPM EAPETMQALR MPFGRVGMVN
     YDTYHRFQEG HTIWDNRYQH STKRAQKKRA KYERRFARFL EKAQDEGLLD DMGDLDISAS
     GTHWTDLAAF GPTDLHNEAP PPSSVVRRRD TPESLSMLKL ALYQRAQRRK SLGLAGNAPP
     HKDEALHLRR SASFCSTWSG ATIGENEPRM RGTGEHRPTD DTGKPLSKRF GLWKSLLFRF
     GDTRGKEL
//