ID A0A2N1J9M9_9BASI Unreviewed; 792 AA.
AC A0A2N1J9M9;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=DUF221-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=MVES_003081 {ECO:0000313|EMBL:PKI83182.1};
OS Malassezia vespertilionis.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX NCBI_TaxID=2020962 {ECO:0000313|EMBL:PKI83182.1, ECO:0000313|Proteomes:UP000232875};
RN [1] {ECO:0000313|EMBL:PKI83182.1, ECO:0000313|Proteomes:UP000232875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NWHC:44797-103 {ECO:0000313|EMBL:PKI83182.1,
RC ECO:0000313|Proteomes:UP000232875};
RA Lorch J.M., Palmer J.M., Vanderwolf K.J., Schmidt K.Z., Verant M.L.,
RA Weller T.J., Blehert D.S.;
RT "A novel species of cold-tolerant Malassezia isolated from bats.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KZ454992; PKI83182.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N1J9M9; -.
DR STRING; 2020962.A0A2N1J9M9; -.
DR OrthoDB; 366603at2759; -.
DR Proteomes; UP000232875; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF83; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000232875};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 28..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 608..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 660..680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..185
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 208..398
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 410..680
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 732..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 792 AA; 89775 MW; 9AC06C5CEC19B50F CRC64;
MASLNSTSPE IPGPTGRTFE GPWLQQQILF SLTLGILSVL AFGVWKRRYP SIYQARHPQQ
SPTMPYQRLR KSIFGWIMPT LVYPDRSVLL NVGIDAAVAL LFFKMIFRYL AMISIWTVVV
LIPVHYYTNG WIDGVSPGEE VHPQHAALAP HPVRAVHLTR DILYENTQLV STYLYTLLAL
HVLWRTYAVY IGFVQGHASV QLRSEAERTV KVSHLPRHLM TSSSLATYFD ELHMPIAHAT
VVQDTTRLDA LLAQRLEVLQ RLERAWAGWL GDPAEAKNYN RAMLLQQTSR VDQPAVPGGA
PRVGTHIVAK RKRPTFAHTR NPFGARVDAI DQLSYQFNQL DRAVHALRRD TFTAMHTAFV
TFRTAAHAEI ASQVVHYPRP GTCITQPACE PRDIIWVNLE PNFWGKRVRK VTLTLMMGVL
LTATLSIGAL LAALVNMRSI RAVLPWLANM MDQDVRLRAF VQKSLPTLLL ILINALVPIA
MEYSTYHERI SSRSNIDHRV MSRYYLYLLF SVVFVFAFTN AWETLKGLAE SPMRMMDKLA
QSLPVARQFS LSYVIFQGLT IQPFQLVELP TIAMRFLHKL FYASTPRGRI HGGYARGMPV
ATLYPQALLI FTLSILYSIV SPLIVLFGAL YFGVAYIVLK YELLNVMEKP YDSHGSAWPL
AIHRCVWALL LFQIFQLSLF SVRKQVVTSL LVLPLLGITA WYLVALHRNY APLTSHLNLY
DIYMAEEHES VTEQQSDVTS TRAGPRTPPT HDPPLSWSHP GLLHVDDEQY KQPSLTSRLP
SLWLPESLDA LA
//
