ID A0A2N1JC24_9BASI Unreviewed; 668 AA.
AC A0A2N1JC24;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=protein-L-isoaspartate(D-aspartate) O-methyltransferase {ECO:0000256|ARBA:ARBA00011890};
DE EC=2.1.1.77 {ECO:0000256|ARBA:ARBA00011890};
GN ORFNames=MVES_001966 {ECO:0000313|EMBL:PKI84111.1};
OS Malassezia vespertilionis.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX NCBI_TaxID=2020962 {ECO:0000313|EMBL:PKI84111.1, ECO:0000313|Proteomes:UP000232875};
RN [1] {ECO:0000313|EMBL:PKI84111.1, ECO:0000313|Proteomes:UP000232875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NWHC:44797-103 {ECO:0000313|EMBL:PKI84111.1,
RC ECO:0000313|Proteomes:UP000232875};
RA Lorch J.M., Palmer J.M., Vanderwolf K.J., Schmidt K.Z., Verant M.L.,
RA Weller T.J., Blehert D.S.;
RT "A novel species of cold-tolerant Malassezia isolated from bats.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. L-
CC isoaspartyl/D-aspartyl protein methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005369}.
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DR EMBL; KZ454990; PKI84111.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N1JC24; -.
DR STRING; 2020962.A0A2N1JC24; -.
DR OrthoDB; 303909at2759; -.
DR Proteomes; UP000232875; Unassembled WGS sequence.
DR GO; GO:0032299; C:ribonuclease H2 complex; IEA:InterPro.
DR GO; GO:0004719; F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd09271; RNase_H2-C; 1.
DR Gene3D; 2.40.128.680; -; 1.
DR Gene3D; 2.70.130.10; Mannose-6-phosphate receptor binding domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR009011; Man6P_isomerase_rcpt-bd_dom_sf.
DR InterPro; IPR044865; MRH_dom.
DR InterPro; IPR000682; PCMT.
DR InterPro; IPR013924; RNase_H2_suC.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00080; pimt; 1.
DR PANTHER; PTHR11579; PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11579:SF0; PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE; 1.
DR Pfam; PF01135; PCMT; 1.
DR Pfam; PF08615; RNase_H2_suC; 1.
DR SUPFAM; SSF50911; Mannose 6-phosphate receptor domain; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51914; MRH; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000232875};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..112
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
SQ SEQUENCE 668 AA; 73762 MW; 80CC58300EE2F700 CRC64;
MDNPTNDNYI LGLWHLSLQG TEGENERGSE LVTAPGVQNA NMVDSKTLFH GEKLYLSQVW
RDGSTCDLNG LPRTVEVQYF CSPDGSHNIA SISEVLTCNY VLVVHVPSLC NVAAFRDIQT
EDVNIIKCRL IVPDDPVERD TYLANAHASK KSHYHPAEID PEFVFATPDQ ELEQMELHAD
STTGKDTLEQ QSSDTVNDQL LPLELDAEHL RDILKSMVEE SRSDLIKNMQ NAGLIKSQRV
AEAMQKVDRA NYVLPQFRSD AYNDSPQSIG FNVTISAPHM HAHAAELLLP YLLPESSVLD
IGSGSGYLLS VLHHLTKSNA RAGHVVGVEH IPELAMISMS NIRSDGLAEE LDSNRIVVAE
TDGRMGTLST VRFANYAGEP RFAPYSAIHV GAAATEIPEM LVEQLDQPGR LIIPVDNNSG
SYQSLWQVDK DVDGAVQRKK LFNVMHIPLS VRLDVTQAST SRTPKVTAHV MPFSVEYTGP
APVDTYFLLR SPANGEPVDA NTATEAVSAF RGRKMHGSRF ALPTSYNAAL FRMQEEVFPL
ESENKVTHKP GRPKVSVSNS IAPPQPVHGA RFLLDEDEEE ETMDAFTFET GHDTPTDLHE
ANDLSINTSE PERAYARHCL KPKVYAGKSI WIWGPDGPID AGDDVYMRTC REWISAIAPA
VRISMAND
//
