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Database: UniProt
Entry: A0A2N3HMV4_9FLAO
LinkDB: A0A2N3HMV4_9FLAO
Original site: A0A2N3HMV4_9FLAO 
ID   A0A2N3HMV4_9FLAO        Unreviewed;       611 AA.
AC   A0A2N3HMV4;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Oxygen sensor histidine kinase NreB {ECO:0000256|ARBA:ARBA00017322};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
DE   AltName: Full=Nitrogen regulation protein B {ECO:0000256|ARBA:ARBA00030800};
GN   ORFNames=CSW08_03695 {ECO:0000313|EMBL:PKQ46276.1};
OS   Confluentibacter flavum.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Confluentibacter.
OX   NCBI_TaxID=1909700 {ECO:0000313|EMBL:PKQ46276.1, ECO:0000313|Proteomes:UP000233435};
RN   [1] {ECO:0000313|EMBL:PKQ46276.1, ECO:0000313|Proteomes:UP000233435}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3B {ECO:0000313|EMBL:PKQ46276.1,
RC   ECO:0000313|Proteomes:UP000233435};
RA   Yu L.;
RT   "Confluentibacter flavum sp. nov., isolated from the saline lake.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Member of the two-component regulatory system NreB/NreC
CC       involved in the control of dissimilatory nitrate/nitrite reduction in
CC       response to oxygen. NreB functions as a direct oxygen sensor histidine
CC       kinase which is autophosphorylated, in the absence of oxygen, probably
CC       at the conserved histidine residue, and transfers its phosphate group
CC       probably to a conserved aspartate residue of NreC. NreB/NreC activates
CC       the expression of the nitrate (narGHJI) and nitrite (nir) reductase
CC       operons, as well as the putative nitrate transporter gene narT.
CC       {ECO:0000256|ARBA:ARBA00024827}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PKQ46276.1}.
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DR   EMBL; PJEO01000014; PKQ46276.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2N3HMV4; -.
DR   OrthoDB; 9760839at2; -.
DR   Proteomes; UP000233435; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR   Gene3D; 1.20.5.1930; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR029095; NarX-like_N.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR   PANTHER; PTHR24421:SF10; NITRATE/NITRITE SENSOR PROTEIN NARQ; 1.
DR   PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF07730; HisKA_3; 1.
DR   Pfam; PF13675; PilJ; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50113; PAC; 1.
PE   4: Predicted;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:PKQ46276.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233435};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT   TRANSMEM        20..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        197..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          327..378
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          513..606
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
SQ   SEQUENCE   611 AA;  68853 MW;  BB6FA281E5BC3C1C CRC64;
     MTKKGISSLD QHTFERLSRL YIIALSAIAL SVIISQILVR KHLRDQESDS SIINVAGRQR
     MLSQKLTKEI VSMSTENDLE KRIALKNNLK ETLALWELSH NGLQMGNDSL GLPGANSAVI
     SKMFHELNPK FDAIRDASKA IIEKIENIPS LPIDMFTNEI TTVKQTEGGF LAIMDDIVNQ
     YDFEADGKVT WLRKLELFIM FITLALLLAE FLFIFWPTAK TVKQSLAELI EAEKKAKKMA
     YDADLLSTAK EKSIKELRAL SQAMDDTLLF ARITSNGVIV HMGNKFSRLF KFNNFSANAN
     FCDVLSIVES ERLAIESLIK SHKKTGWQGE VKATTKDNQP VWLEMAIIPF NPTDDKTELL
     IIASEITKRK EGQMEIERLT KESFEERMNQ QKVISSKIIE NQEKEQNRIA KDVHDGIGQM
     LTGLKFNLES IDISDINKTA KKIEHLKELT SNIIKGVRTA TFNLTPPELA DHGIVPALTK
     LTTELTKLTG KNIVLYNKTD FTQRLDSLAE INIYRITQEA INNAIKYADS THILVSISNS
     DEILSIVIDD NGKGFDPNKI KNVKNGDGGM GMTFMRERIK YINGRLFLNS DLKKGTRVTL
     NIPLQELSIT T
//
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