ID A0A2N3N2N2_9PEZI Unreviewed; 983 AA.
AC A0A2N3N2N2;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Sodium/calcium exchanger membrane region domain-containing protein {ECO:0000259|Pfam:PF01699};
GN ORFNames=jhhlp_007428 {ECO:0000313|EMBL:PKS06677.1};
OS Lomentospora prolificans.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Microascales; Microascaceae; Lomentospora.
OX NCBI_TaxID=41688 {ECO:0000313|EMBL:PKS06677.1, ECO:0000313|Proteomes:UP000233524};
RN [1] {ECO:0000313|EMBL:PKS06677.1, ECO:0000313|Proteomes:UP000233524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHH-5317 {ECO:0000313|EMBL:PKS06677.1,
RC ECO:0000313|Proteomes:UP000233524};
RX PubMed=28963165; DOI=10.1534/g3.117.300107;
RA Luo R., Zimin A., Workman R., Fan Y., Pertea G., Grossman N., Wear M.P.,
RA Jia B., Miller H., Casadevall A., Timp W., Zhang S.X., Salzberg S.L.;
RT "First Draft Genome Sequence of the Pathogenic Fungus Lomentospora
RT prolificans (Formerly Scedosporium prolificans).";
RL G3 (Bethesda) 7:3831-3836(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. {ECO:0000256|ARBA:ARBA00008170}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKS06677.1}.
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DR EMBL; NLAX01001034; PKS06677.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N3N2N2; -.
DR STRING; 41688.A0A2N3N2N2; -.
DR VEuPathDB; FungiDB:jhhlp_007428; -.
DR InParanoid; A0A2N3N2N2; -.
DR OrthoDB; 5482417at2759; -.
DR Proteomes; UP000233524; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR12266:SF0; MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN; 1.
DR PANTHER; PTHR12266; NA+/CA2+ K+ INDEPENDENT EXCHANGER; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233524};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 775..796
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 802..821
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 828..850
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 870..898
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 919..942
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 954..978
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 107..245
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 810..968
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 406..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 983 AA; 106963 MW; E266C7DAE7DAE76E CRC64;
MSLIAPSKGR PSAWLRRRPF YAAFAIASFL ILSSYLQAFL SGVHSESAAL YPRAGSVECR
DVHHAQDVCA FVRANCDDEQ PGLVPYLTLY YCTFGYARIA GFVLLLIWLG LLFSTIGIAA
SDFFTPNLQT IASVLSMPEN LTGVTFLAVG NGSPDLFSTV MSMRSNSAAM AVGELIGAAS
FITAIVAGSI VMISEFKVDK RSFVRDLLFF IFAVCLTLSF LLDGHLHFFE CVIMIAYYGF
YVLFVSGAHW YSTAQARRAA LAENRARAIE AVVEANGEAR YEDYPGSTAH DARAQALSIH
SARGSTSSMP RIEIEGDRTT EDEEDEGRER GKWIAAEIAS NMRVRRPTVS RRPTAAFIRP
SLVGALELNS AFEHFRKESR SRPDYLGHLR RHSVQNVPRV ARIRSDAPTR PTIAVDPTSP
PSRERAHSHT GNVAEVTPHT SEPALPTQVL ELRHENNLPG SPSGSLAPSR AASSTKSFQL
DGNLAVPPIP PPGARQDYFI TTAGSARPSP RLESLHLHIP SRRSSTSEHS DTLSPFPGYV
ESPMPMSPNS EAGPPSFGLP PPTITSPNWI LAEGDGETEI PNRYKWWPYF LLPAPEVIMA
TLFPMLQNWS EKTFADAFVS VLSVPSFFLL SITLPVVDAR GSEIEDASDG SASSATNPPR
WQTANDEWEL FRRHRRSTIA SNRTLGYHSV SPRSPASIDE GMALGVGRLA LPKIVRHPDV
AFGEADLEEV LTTSDEGAGW TKWQVLLQTL AGPPFSVFIA CSVVMEQPTE QVVDAVRWSL
VASGVLFLTV LLTTKADQRP RYHSLLCFPG FLVSVSWIAV IAGEVVGVLK AIGVIWSISE
AILGLTIFAA GNSVGDWVSD YTIASLGSPV MAFAGCIGGP MLNILLGIST GGLIGMASKA
RRKKEKHPDR PIVYEPYKIR ISGSLVVSAA TLLLTLLALL TFVSLNKWVF SRRLGIGLIS
LWCISTGVNL MIEILGLWTE VST
//
