ID A0A2N3NAE0_9PEZI Unreviewed; 684 AA.
AC A0A2N3NAE0;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 28-JUN-2023, entry version 16.
DE RecName: Full=Phosphoinositide phospholipase C {ECO:0000256|RuleBase:RU361133};
DE EC=3.1.4.11 {ECO:0000256|RuleBase:RU361133};
GN ORFNames=jhhlp_004021 {ECO:0000313|EMBL:PKS09406.1};
OS Lomentospora prolificans.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Microascales; Microascaceae; Lomentospora.
OX NCBI_TaxID=41688 {ECO:0000313|EMBL:PKS09406.1, ECO:0000313|Proteomes:UP000233524};
RN [1] {ECO:0000313|EMBL:PKS09406.1, ECO:0000313|Proteomes:UP000233524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHH-5317 {ECO:0000313|EMBL:PKS09406.1,
RC ECO:0000313|Proteomes:UP000233524};
RX PubMed=28963165; DOI=10.1534/g3.117.300107;
RA Luo R., Zimin A., Workman R., Fan Y., Pertea G., Grossman N., Wear M.P.,
RA Jia B., Miller H., Casadevall A., Timp W., Zhang S.X., Salzberg S.L.;
RT "First Draft Genome Sequence of the Pathogenic Fungus Lomentospora
RT prolificans (Formerly Scedosporium prolificans).";
RL G3 (Bethesda) 7:3831-3836(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-
CC diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456,
CC ChEBI:CHEBI:203600; EC=3.1.4.11;
CC Evidence={ECO:0000256|RuleBase:RU361133};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKS09406.1}.
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DR EMBL; NLAX01000010; PKS09406.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N3NAE0; -.
DR STRING; 41688.A0A2N3NAE0; -.
DR VEuPathDB; FungiDB:jhhlp_004021; -.
DR InParanoid; A0A2N3NAE0; -.
DR OrthoDB; 2900494at2759; -.
DR Proteomes; UP000233524; Unassembled WGS sequence.
DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 2.
DR InterPro; IPR001192; PI-PLC_fam.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR InterPro; IPR001711; PLipase_C_Pinositol-sp_Y.
DR PANTHER; PTHR10336:SF82; PHOSPHOINOSITIDE PHOSPHOLIPASE C; 1.
DR PANTHER; PTHR10336; PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN; 1.
DR Pfam; PF00388; PI-PLC-X; 1.
DR Pfam; PF00387; PI-PLC-Y; 1.
DR PRINTS; PR00390; PHPHLIPASEC.
DR SMART; SM00148; PLCXc; 1.
DR SMART; SM00149; PLCYc; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
DR PROSITE; PS50008; PIPLC_Y_DOMAIN; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|RuleBase:RU361133};
KW Lipid degradation {ECO:0000256|RuleBase:RU361133};
KW Lipid metabolism {ECO:0000256|RuleBase:RU361133};
KW Reference proteome {ECO:0000313|Proteomes:UP000233524}.
FT DOMAIN 455..565
FT /note="PI-PLC Y-box"
FT /evidence="ECO:0000259|PROSITE:PS50008"
FT REGION 242..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..258
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 77260 MW; B87C76858AC48F6D CRC64;
MRFWLRQRKV EPVERTEIKP RRPPLRSQSS SFIRPRAILN RLSTIASLRL NTDSKESSEI
VEVVEVPIRQ KLPSFHISPV AHRHLESEFR RLSHPHLILK REKFAEFLAT VQGEENIRLN
KARYRFHEFC DIIMLYYGFD AIQRPLSYKK DLSKPITHYF INSSHNTYLC GNQFTSTSSP
EPYRTALLRG CRCIEIDVLN GDSPSLDSKK PTDHKKTVSH ESIPLLAGSL MDKVEETIHS
TRQFIRDHSP RPTRRRLDPN QTSDSSSQTQ TSEGGSSISL SPNGALEKPV RGRSLLSKLS
YPKTEPIVAH KWAATRPCGF REVCKAIRES AFQTTQLPVI VSLEVLADED QQEVMVQIMK
EEWAGLLLSE PLEGCDPKFH APRLEDLKNK ILIKVKKATP KPLGSASLGG LTPGGSHGDS
TDDDRCSFTT KTSPAMESPN PADLGAKRVA ICRNLSNLSI YTFSQSFKGF DNRTTKKPGH
IFSISESRIH ELVANNPFEI FQHNKNFLMR AFPDGTRVNS SNPDPSPFWR QGVQMVAMNR
QNLDEGMILN EGMFADEEGW VLKPKGYGVT DKGTESYHDA VPLTTTDLKI SILAGQKICS
ADHCEDDDGK DRRANLRPSV KCELQYEKCD TRKGEKKDKM ISQVVECKKK TKPSETDHPD
FGEGGCSFSF EGIRGTLQEF VFIR
//
