ID   A0A2N3NI23_9PEZI        Unreviewed;       524 AA.
AC   A0A2N3NI23;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   13-SEP-2023, entry version 14.
DE   RecName: Full=fumarate hydratase {ECO:0000256|ARBA:ARBA00012921};
DE            EC=4.2.1.2 {ECO:0000256|ARBA:ARBA00012921};
GN   ORFNames=jhhlp_001407 {ECO:0000313|EMBL:PKS12109.1};
OS   Lomentospora prolificans.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Microascales; Microascaceae; Lomentospora.
OX   NCBI_TaxID=41688 {ECO:0000313|EMBL:PKS12109.1, ECO:0000313|Proteomes:UP000233524};
RN   [1] {ECO:0000313|EMBL:PKS12109.1, ECO:0000313|Proteomes:UP000233524}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHH-5317 {ECO:0000313|EMBL:PKS12109.1,
RC   ECO:0000313|Proteomes:UP000233524};
RX   PubMed=28963165; DOI=10.1534/g3.117.300107;
RA   Luo R., Zimin A., Workman R., Fan Y., Pertea G., Grossman N., Wear M.P.,
RA   Jia B., Miller H., Casadevall A., Timp W., Zhang S.X., Salzberg S.L.;
RT   "First Draft Genome Sequence of the Pathogenic Fungus Lomentospora
RT   prolificans (Formerly Scedosporium prolificans).";
RL   G3 (Bethesda) 7:3831-3836(2017).
CC   -!- SIMILARITY: Belongs to the class-II fumarase/aspartase family. Fumarase
CC       subfamily. {ECO:0000256|ARBA:ARBA00009084}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PKS12109.1}.
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DR   EMBL; NLAX01000004; PKS12109.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2N3NI23; -.
DR   STRING; 41688.A0A2N3NI23; -.
DR   VEuPathDB; FungiDB:jhhlp_001407; -.
DR   InParanoid; A0A2N3NI23; -.
DR   OrthoDB; 1341425at2759; -.
DR   Proteomes; UP000233524; Unassembled WGS sequence.
DR   GO; GO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro.
DR   GO; GO:0004333; F:fumarate hydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006106; P:fumarate metabolic process; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   CDD; cd01362; Fumarase_classII; 1.
DR   Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR   Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR   Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR   HAMAP; MF_00743; FumaraseC; 1.
DR   InterPro; IPR005677; Fum_hydII.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR018951; Fumarase_C_C.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   NCBIfam; TIGR00979; fumC_II; 1.
DR   PANTHER; PTHR11444; ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE; 1.
DR   PANTHER; PTHR11444:SF1; FUMARATE HYDRATASE, MITOCHONDRIAL; 1.
DR   Pfam; PF10415; FumaraseC_C; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; L-aspartase-like; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233524}.
FT   DOMAIN          66..399
FT                   /note="Fumarate lyase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00206"
FT   DOMAIN          465..517
FT                   /note="Fumarase C C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF10415"
SQ   SEQUENCE   524 AA;  56682 MW;  4E24336B37B7BA15 CRC64;
     MRPSVRLPQV LAAAARGNAL ALRCNSLTAP ARLSARLPTT YKLTRRSLHQ TTLKMAATRT
     ESDAFGEIQV PSDKYWGAQT ERSLENFRIN QPQDRMPFPI VKAFGILKGA AATVNMRYGL
     DPKIGKAIQQ AAAEVAEGKL TDHFPLVVWQ TGSGTQSNMN ANEVISNRAI EILGGEMGSK
     KPVHPNDHVN RSASSNDTFP TVMHIAGVLE IEGDLLPALR SLRDALQKKV DTFEAKNIIK
     IGRTHLQDAT PLTLAQEFSG YVAQLDSSIK RVESSLPDLR LLAQGGTAVG TGINTFEGFA
     EAIAEEVTKM TGTEFKTAPN KFEALAAHDA VVQAHGSLNT LAAVLTKIAQ DIRYLGSGPR
     CGLGELILPE NEPGSSIMPG KVNPTQCEAL TMVCAQVMGN HVATTIGGMN GQFELNVYKP
     LIIRNLLHSI RILADGMRSF EKNLVDGLQA NEEKIASIMK ESLMLVTCLN PKIGYDMASK
     VAKNAHKKGL TLKQSALELN ALTEEEFDTL VKPELMVGPK PYKA
//