ID A0A2N3PQL3_9PROT Unreviewed; 1048 AA.
AC A0A2N3PQL3;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=CusA/CzcA family heavy metal efflux RND transporter {ECO:0000313|EMBL:PKU22672.1};
GN ORFNames=CWS72_20280 {ECO:0000313|EMBL:PKU22672.1};
OS Telmatospirillum siberiense.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Rhodospirillaceae; Telmatospirillum.
OX NCBI_TaxID=382514 {ECO:0000313|EMBL:PKU22672.1, ECO:0000313|Proteomes:UP000233293};
RN [1] {ECO:0000313|Proteomes:UP000233293}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=26-4b1 {ECO:0000313|Proteomes:UP000233293};
RA Hausmann B., Pjevac P., Schreck K., Herbold C.W., Daims H., Wagner M.,
RA Pester M., Loy A.;
RT "Draft genome sequence of Telmatospirillum siberiense 26-4b1T, an
RT acidotolerant peatland alphaproteobacterium potentially involved in sulfur
RT cycling.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKU22672.1}.
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DR EMBL; PIUM01000028; PKU22672.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N3PQL3; -.
DR OrthoDB; 9758757at2; -.
DR Proteomes; UP000233293; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF19; CATION EFFLUX SYSTEM PROTEIN CUSA; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233293};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 338..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 864..881
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 888..908
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 914..938
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 975..992
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1004..1030
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1048 AA; 114901 MW; 5A3470D59B0D67EB CRC64;
MIASIIRWSV KNTFLVLLAT VAIIAAGVYA TEHLPLDALP DLSDTQVILY TDYPGQAPQV
VEDQVTYPLT TAMLSVPKSK VVRGFSMFGT SFVYVVFEDG TDIYWARSRV LEYLSFAAKR
LPPGVTPSLG PDATGVGWVY QYVVQAKNKS LAELRTIQDW FLRYQLAKAE GVAEVAGIGG
FVQQYQVVVD PQKLQSYNIS LDKVSSAIRK SNTDVGGRSI EMAETEFIVR GRGYLRSIED
LGKIALKAQN GTPILLRDVA RVELGPDERR GFAELNGEGE AVSGIVVQRY GQNALDVIQN
VKDKLAEIAS GLPEGVSISS VYDRSDLILR AVHTLKRTLI EESLIVAAVC IIFLLHLRSA
LVAILMLPVG VLISIIVMQF LGLTSNIMSL GGIAIAVGAM VDAAIVMIEN AHKHLERMKP
GDSRVQALIE AAIEVGPSLF FGLLIITVSF LPVFTLESQE GRMFKPLAFT KTFSMAGAAV
LSVTLVPVLM ALFVRGKILP EHKNPINRLL IWLYRPLIRM VLNWKGATIL LALAILGISA
YPISQVGSEF MPRLYEGTLL YMPTTLPGVS VTKAAELMQT QDKIIKSFPE VESVFGKAGR
ADTATDPAPI EMFETTINLK PQEEWPAGMT IDQLIADMDK ALQIPGVSNA WTMPLRGRID
MLSTGIRTPI GIKVFGKDLT EMERVAKQIE QVVKAVPGTT SAYAERIMGG YYLEILPDRD
ALARYGLVVG DLQEVILTAM GGEMVTTTVE GRERFSVNVR YPRDFRSDPQ AIGTRILVPT
MDGQHIPLGQ LAKIQLTKGP STIRTENALL SAYIYVDIRD RDIGGYVADA KKAVETQVQM
PPGYYATWSG QFEYMERAKQ KMKIVVPATI FVIFLLLYVN FKRLTETLIV MLSLPFALIG
GGWLMWWLGF NMSVAVAVGF IALAGVAAET GVVMLIYLDH ALQAVRAERE KNGEPLTRAD
LYAAIMEGAV ERVRPKMMTV VAIMAGLLPI MWSTGTGSEV MRRIAMPMVG GMISSTVLTL
VVIPAIYALV KEYTLLRHPG AQAPREKK
//
