ID A0A2N3PT30_9PROT Unreviewed; 1051 AA.
AC A0A2N3PT30;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN ORFNames=CWS72_15925 {ECO:0000313|EMBL:PKU23554.1};
OS Telmatospirillum siberiense.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Rhodospirillaceae; Telmatospirillum.
OX NCBI_TaxID=382514 {ECO:0000313|EMBL:PKU23554.1, ECO:0000313|Proteomes:UP000233293};
RN [1] {ECO:0000313|Proteomes:UP000233293}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=26-4b1 {ECO:0000313|Proteomes:UP000233293};
RA Hausmann B., Pjevac P., Schreck K., Herbold C.W., Daims H., Wagner M.,
RA Pester M., Loy A.;
RT "Draft genome sequence of Telmatospirillum siberiense 26-4b1T, an
RT acidotolerant peatland alphaproteobacterium potentially involved in sulfur
RT cycling.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU364070}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU364070}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942,
CC ECO:0000256|RuleBase:RU364070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKU23554.1}.
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DR EMBL; PIUM01000019; PKU23554.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N3PT30; -.
DR OrthoDB; 9806532at2; -.
DR Proteomes; UP000233293; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF11; EFFLUX PUMP MEMBRANE TRANSPORTER; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW Cell membrane {ECO:0000256|RuleBase:RU364070};
KW Membrane {ECO:0000256|RuleBase:RU364070};
KW Reference proteome {ECO:0000313|Proteomes:UP000233293};
KW Transmembrane {ECO:0000256|RuleBase:RU364070};
KW Transmembrane helix {ECO:0000256|RuleBase:RU364070};
KW Transport {ECO:0000256|RuleBase:RU364070}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 395..419
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 472..499
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 543..564
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 875..896
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 903..927
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 933..956
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 977..998
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 1010..1036
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT DOMAIN 368..497
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1051 AA; 114475 MW; B951F144E3765C30 CRC64;
MTLSRFFIDR PIFAGVISFV IFLAGLASIF QLPISEYPEV VPPTVVVKAQ FPGANPKVIA
ETVATPLEEQ INGTENMLYM SSQASSDGFL TLTVTFKLGT DPNLAQELVQ NRVNQALPRL
PDVTRQLGVT TTKSSPDLTM VVHLTSPNGR YDMLYLRNYA VLNVKDQLAK IQGVGSVQLF
GSGDYAMRIW LNPQKVAERG LTPQEVVGAI RRQNVQVSAG MIGGPPYDKG VELQLPINAQ
GRLQDAEQFG EMIVKRNEQG AITRLKDIAR VEIDAAEFGL RSLLDNKSAV AIPVFQAPGS
NAIEISNQVR KTMADLKQHF PEGVDYSIVY DPTVFVRGSI EAVVHTLLEA LVLVVLVVIV
FLQTWRASII PLLAVPVSIV GTFAIMHLFG FSINALSLFG LVLAIGIVVD DAIVVVENVE
RNIEEGLAPR EATITAMREV TSPIIAITLV LCAVFVPIAF ISGLTGQFYR QFALTIAFST
IVSAFNSLTL SPALAAILLK SHDAPKDRLT RAVDRLFGRF FNAFNRFFQR SSRRYSRGVT
ATLGHKSASM GIYLLLLGAT YLGFQQVPPG FVPIQDKQYL VSFAQLPEGA TLDRTEKVIR
EMSDIMLKEP GVESAIAFPG LSINGFINSS SAGIVFVSLK PFEERKSKDL SGFAISQSLQ
RKFAGVKDAF IAVFPPPPVQ GLGTIGGFKL QVEDRTDQGY EALDAAIRSV IAKARQTPEL
TGVFSSYKIN VPQLYADLDR TKAMQLGVDV QDVFDTMQIY LGSLYINDFN KFGRTYQVIA
QADRQFRSQP DDILRLQTRN LEGRMVPLGS VIRVSDTTGP ESAMRYNGFR SADLNGGPAP
GVSSGQAQAA MVRILSETLP KGMEFEWTEL TYQQILAGNT AIIVFPICVL LVFLVLAAKY
ESLFLPLAII LIVPMCLLSA IGGVWATGGD NNIFTQIGLF VLAGLACKNA ILIVEFAREM
EALGRGTVES AVEAAKLRLR PILMTSFAFI MGVVPLVLSS GAGAEMRHAM GIAVFFGMLG
VTFFGLFLTP VFYVLLRGIE KRIVGTKVSQ A
//
