ID A0A2N3Y8Z4_SACSN Unreviewed; 1194 AA.
AC A0A2N3Y8Z4;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=A8926_7561 {ECO:0000313|EMBL:PKW19394.1};
OS Saccharopolyspora spinosa.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=60894 {ECO:0000313|EMBL:PKW19394.1, ECO:0000313|Proteomes:UP000233786};
RN [1] {ECO:0000313|EMBL:PKW19394.1, ECO:0000313|Proteomes:UP000233786}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44228 {ECO:0000313|EMBL:PKW19394.1,
RC ECO:0000313|Proteomes:UP000233786};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 Actinobacteria strains.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKW19394.1}.
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DR EMBL; PJNB01000001; PKW19394.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N3Y8Z4; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000233786; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 7..74
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1194 AA; 131646 MW; FFB5F1D3D88B313A CRC64;
MPVDPFVHLH VHTEYSMLDG AAKVGALFAE AERLGMPAVG MTDHGNMFGA DEFYQQACRA
GIKPIIGIEA YLAPTSRFHK KPVFWGEAKQ RGTDEFGEGG DVSGAGAYTH MTMLARNATG
LRNLFTLSSR ASFEGYYRKP RMDRELISEF SEGIIATTGC PSGEVQTRLR LRQFDEALQA
AADYRDIFGA ENFFLELMDH GLPIERSVRQ GLLKISRELG LKPLATNDSH YVTVDQAESH
GALLCVQSGK TLSDESRFKF DGDGYYLKSA GEMREYWDQE VPGAADSTLL VAEMVESYKD
VWSFQDRMPR VTDGSGRSER ELLEAEVRQY LPTRYPDGAS EECLERIKVE LDVLDTKGYC
AYFLVVGDLT RWAKSQGIHV GPGRGSAAGS LLAYILHITN LDPLEHGLIF ERFLNPERDS
PPDIDLDFDD RRRDEVLQYA INKYGRDKVA QVITFGKIKT KAAIKDSARV HHGQPGFAIA
DKISKALPPP IAAKDIPLSG IVDPQHERYA EAAEVRSLIE TDPAVSQIFD TARGLEGLIR
NAGVHACAVI LSSQPLLGTV PLWARDDGSI ITGWDYPSCE AIGLLKMDFL GLSNLTILGD
ALTMVKENHD RDIDLSNLGL DDKTTYEMLA RGESLGVFQF EGGGMRELLK RLQPTEFGDL
VAANALYRPG PMDVNAHLDY ADRKNGRKAI EPIHPDLEDD LRDILDETYG LIVYQEQIMA
IAQKVAGYSL GRADILRRAM GKKKKSVLDQ EFEGFQAGMR ANGYRDEAIT KLWETVLPFA
GYAFNKSHAA GYALVAYWTA YLKANYPAEY MAGLLTSNGD NKDKMAVYLA ECRRMGVKVL
SPDVNDSRDT FAAVGSDIRF GMSAIRNVGS NVVASIVTTR KEKGRYTSFT DFLDKSEILA
CNKRVIESLI KAGAFDSLGH TRMSLVQHHE AAVDAVIGLK RQQAMGQFDL FGADTSEDSA
DASPLAHLHF THEEWPRKQL LSYEREMLGL YVSAHPLDGA ERLLAPYQDT GIADLVGGER
EFGNGKEQLK IAGMISGIQR RINKNGHPWA IVTLEDLDAS VEVLFFPKSY EMFADCLMED
TALAVKGRIN EREGTISVFA SDAVPVDISA AETDPGTDPA FVIKVPVGRV NQSLVAELKR
TLRAHTGTTP VQLKLQSPRG TTRLALSSDY FVSTENGLQG ELKGLLGAGC FEAY
//