ID A0A2N3YGZ7_9MICO Unreviewed; 705 AA.
AC A0A2N3YGZ7;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=ATL31_0924 {ECO:0000313|EMBL:PKW26118.1};
OS Phycicoccus duodecadis.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Intrasporangiaceae;
OC Phycicoccus.
OX NCBI_TaxID=173053 {ECO:0000313|EMBL:PKW26118.1, ECO:0000313|Proteomes:UP000233781};
RN [1] {ECO:0000313|EMBL:PKW26118.1, ECO:0000313|Proteomes:UP000233781}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12806 {ECO:0000313|EMBL:PKW26118.1,
RC ECO:0000313|Proteomes:UP000233781};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 Actinobacteria strains.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKW26118.1}.
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DR EMBL; PJNE01000001; PKW26118.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N3YGZ7; -.
DR OrthoDB; 9806690at2; -.
DR Proteomes; UP000233781; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF45; ATP-DEPENDENT DNA HELICASE UVRD2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50967; HRDC; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000233781}.
FT DOMAIN 15..297
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 301..547
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT DOMAIN 626..705
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT BINDING 36..43
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 705 AA; 75551 MW; 0D46F22672B8FF0F CRC64;
MTTLPVHPGA DAVLDALDPE QREVAAHPRG PMCVLAGAGT GKTRAITHRI AYGVLSGTYQ
PQRVLAVTFT ARAAGEMRTR LRDLGVGGVQ ARTFHAAALR QLHYFWPQAI GGAAPEVMPH
KASAVAEAGG RLRLRLDSPG IRDAAAEIEW AKVSMLTADG YAAAARAQRR EPPAGLDATA
MARLMSTYED VKTDRGVIDF EDVLLLTAGI LGEHEQVARA VRAQYRHFVV DEYQDVNRLQ
QTLLDLWLGG RDDVCVVGDP AQTIYSFTGA SPEHLLGFRT RHPDARVVEL VRNYRSTPQV
VGLANLVLRS PGGGRRSGSV ELRAQRPEGA APELLVADDD PAEAEQIATR AAALVEAGHP
ASEIAVLFRT NGQSERLESA LAERGIPYLV RGGERFFSRK EVRDAVVLLR GAARTDDGEV
PLPDLVRDVL LGAGWTREAP TSGGAARERW ESLAALAALA DDLAATTPDA RLPVFVGELA
ERAAAQHAPT VQGVTLASLH AAKGLEWDTV FLSGCSDGLL PITMAETPDE IEEERRLLYV
GVTRARERLV LSYARARTPG AKPTRRPSRF LDGTEAVLGA AARSRPKTAK KVKAVPAAAR
TTCRVCDAGL ATAKERTIGR CADCPPSMDE RLFETLREWR LATAKENDVP AFVVFTDATL
TAIAERVPAD RAALAGIAGV GPAKLDRYGD AVLEIVKDFS AAENG
//
