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Database: UniProt
Entry: A0A2N4UHU5_9BURK
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ID   A0A2N4UHU5_9BURK        Unreviewed;       383 AA.
AC   A0A2N4UHU5;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada {ECO:0000313|EMBL:PLC54592.1};
GN   ORFNames=CR155_07430 {ECO:0000313|EMBL:PLC54592.1};
OS   Pollutimonas nitritireducens.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Pollutimonas.
OX   NCBI_TaxID=2045209 {ECO:0000313|EMBL:PLC54592.1, ECO:0000313|Proteomes:UP000234328};
RN   [1] {ECO:0000313|EMBL:PLC54592.1, ECO:0000313|Proteomes:UP000234328}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JR1/69-2-13 {ECO:0000313|EMBL:PLC54592.1,
RC   ECO:0000313|Proteomes:UP000234328};
RA   Grouzdev D.S., Tourova T.P., Goeva M.A., Babich T.L., Sokolova D.S.,
RA   Abdullin R., Poltaraus A.B., Toshchakov S.V., Nazina T.N.;
RT   "Two draft genome sequences of Pusillimonas sp. strains isolated from a
RT   nitrate- and radionuclide-contaminated groundwater in Russia.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a
CC         thymidine in DNA + S-methyl-L-cysteinyl-[protein];
CC         Xref=Rhea:RHEA:53428, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:10132,
CC         Rhea:RHEA-COMP:13555, Rhea:RHEA-COMP:13556, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:82612, ChEBI:CHEBI:137386, ChEBI:CHEBI:137387;
CC         EC=2.1.1.63; Evidence={ECO:0000256|ARBA:ARBA00001286};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein]
CC         = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein];
CC         Xref=Rhea:RHEA:24000, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:10132,
CC         Rhea:RHEA-COMP:11367, Rhea:RHEA-COMP:11368, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:82612, ChEBI:CHEBI:85445, ChEBI:CHEBI:85448; EC=2.1.1.63;
CC         Evidence={ECO:0000256|ARBA:ARBA00001596};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000409-3};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR000409-3};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PLC54592.1}.
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DR   EMBL; PDNV01000004; PLC54592.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2N4UHU5; -.
DR   OrthoDB; 9802228at2; -.
DR   Proteomes; UP000234328; Unassembled WGS sequence.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0003908; F:methylated-DNA-[protein]-cysteine S-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd06445; ATase; 1.
DR   Gene3D; 3.40.10.10; DNA Methylphosphotriester Repair Domain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   Gene3D; 3.30.160.70; Methylated DNA-protein cysteine methyltransferase domain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR035451; Ada-like_dom_sf.
DR   InterPro; IPR004026; Ada_DNA_repair_Zn-bd.
DR   InterPro; IPR016221; Bifunct_regulatory_prot_Ada.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR001497; MethylDNA_cys_MeTrfase_AS.
DR   InterPro; IPR014048; MethylDNA_cys_MeTrfase_DNA-bd.
DR   InterPro; IPR036217; MethylDNA_cys_MeTrfase_DNAb.
DR   InterPro; IPR036631; MGMT_N_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   NCBIfam; TIGR00589; ogt; 1.
DR   PANTHER; PTHR10815:SF14; BIFUNCTIONAL TRANSCRIPTIONAL ACTIVATOR/DNA REPAIR ENZYME ADA; 1.
DR   PANTHER; PTHR10815; METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE; 1.
DR   Pfam; PF02805; Ada_Zn_binding; 1.
DR   Pfam; PF01035; DNA_binding_1; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   PIRSF; PIRSF000409; Ada; 1.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF57884; Ada DNA repair protein, N-terminal domain (N-Ada 10); 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF53155; Methylated DNA-protein cysteine methyltransferase domain; 1.
DR   SUPFAM; SSF46767; Methylated DNA-protein cysteine methyltransferase, C-terminal domain; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
DR   PROSITE; PS00374; MGMT; 1.
PE   4: Predicted;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000313|EMBL:PLC54592.1};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000409-3};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:PLC54592.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000234328};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:PLC54592.1};
KW   Zinc {ECO:0000256|PIRSR:PIRSR000409-3}.
FT   DOMAIN          96..192
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000259|PROSITE:PS01124"
FT   REGION          360..383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        46
FT                   /note="Nucleophile; methyl group acceptor from
FT                   methylphosphotriester"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000409-1"
FT   ACT_SITE        330
FT                   /note="Nucleophile; methyl group acceptor from either O6-
FT                   methylguanine or O4-methylthymine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000409-1"
FT   BINDING         46
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000409-3"
SQ   SEQUENCE   383 AA;  41430 MW;  96AA8AC44D0BD03D CRC64;
     MIVQPHSDRS AANTVEQDPR WAAVQARDPA ADGNFVYAVK TTGVYCHPSS SSRHPHPANV
     EFFSTPQAAA AAGYRPSRRA SPDHTAMAAR RAKLVADACR YIETAYNMPT LADLAARADM
     SPPHFHRVFK AETGLTPKGY ADAHRAARLR STLTQPGSIT DAIYDAGFGS NSRFYEASDR
     MLGMRPKDYR AGGVNTQIRF AVGECSLGSI LVAQSARGVC AILMGDDPDR LVRDLQDQFP
     RATLVGGDAD FERLIAEVVG FVESPCVGLN LPLDVRGTAF QQRVWQALLE IPAGTTATYT
     EIASRIGMPT AVRAVASACG ANRLAVAIPC HRVVRRDGSL SGYRWGVDRK RQLLEREAAL
     QPDMPGHGVN QTGITEADVE QRP
//
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