ID A0A2N4X949_9BACT Unreviewed; 854 AA.
AC A0A2N4X949;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=Zinc-dependent metalloprotease {ECO:0000313|EMBL:PLK42933.1};
GN ORFNames=C0V77_18665 {ECO:0000313|EMBL:PLK42933.1};
OS Emticicia sp. TH156.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Spirosomataceae;
OC Emticicia.
OX NCBI_TaxID=2067454 {ECO:0000313|EMBL:PLK42933.1, ECO:0000313|Proteomes:UP000234203};
RN [1] {ECO:0000313|EMBL:PLK42933.1, ECO:0000313|Proteomes:UP000234203}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TH156 {ECO:0000313|EMBL:PLK42933.1,
RC ECO:0000313|Proteomes:UP000234203};
RA Cai h.;
RT "genomes of bacteria within cyanobacterial aggregates.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLK42933.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; PKRS01000010; PLK42933.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N4X949; -.
DR OrthoDB; 9776599at2; -.
DR Proteomes; UP000234203; Unassembled WGS sequence.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04276; ZnMc_MMP_like_2; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR InterPro; IPR033413; DUF5117.
DR InterPro; IPR033428; DUF5118.
DR InterPro; IPR032534; EcxA_zinc-bd.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR034032; Zn_MMP-like_bac.
DR PANTHER; PTHR38478; PEPTIDASE M1A AND M12B; 1.
DR PANTHER; PTHR38478:SF1; ZINC DEPENDENT METALLOPROTEASE DOMAIN LIPOPROTEIN; 1.
DR Pfam; PF16313; DUF4953; 1.
DR Pfam; PF17148; DUF5117; 1.
DR Pfam; PF17162; DUF5118; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:PLK42933.1};
KW Metalloprotease {ECO:0000313|EMBL:PLK42933.1};
KW Protease {ECO:0000313|EMBL:PLK42933.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000234203};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..854
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014801309"
FT DOMAIN 57..106
FT /note="DUF5118"
FT /evidence="ECO:0000259|Pfam:PF17162"
FT DOMAIN 115..317
FT /note="DUF5117"
FT /evidence="ECO:0000259|Pfam:PF17148"
FT DOMAIN 450..755
FT /note="EcxA zinc-binding"
FT /evidence="ECO:0000259|Pfam:PF16313"
FT REGION 22..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 854 AA; 96715 MW; ECF0BDD89B9559A7 CRC64;
MKLLRLALVP CAIFGMTLTG NAQKKDDKKK EEPAKTTQTP TATPPVVKPA ETPKPGPKPY
KDVITDKAKT SKGLITVHKI DEKYFFEIAD TLLGRDIMTV TRYSKTAAGG GIFGGEEVNR
QMIRWEKGPD NKIFLRSISI VMSSPDSTKP IFQAVRNSSA DPIVGAFDIK AIKKDTVSVI
EVTDFFKADN QIFSLDPVSK QLLKITAQLP DRSYIQHIRS YPINTEIRTV KTFGVVPPSV
SLMPIPQIGQ YLPASRDAGV VTMEFNTSMI LLPKVPMRKR FFDQRVGYFA NQYSVFGEES
QKSDNEVFAV RWRLEPKSKE DAERQKRGEA IEPKKPIIYY IDPATPKKWQ KYLKAGVDDW
QKAFEKAGWK NAIRGEYLDP KDSLSLEDAR YSVIRYFAAD IQNAYGPNVH DPRSGEILES
HIGWYHNVMR LLRNWYMIQT AAVDPRARTK NFSDELMGEL VRFVSSHEVG HTLGLRHNMG
ASSATPVEKL RDKNWVAKNG HTSSIMDYAR FNYVAQPEDG VTDLFPRIGD YDDWAIKWGY
GYFADAKDAK EEKKMLNELT KEATKDPRKR FGTEISPYDP RYQTEDLSDN AMKASDYGIK
NLQRILPNLT EWSKEDGEFY KELSELYGNV VGQYRRYIGH VTKNVGGVYD TPKTYDMEGN
VYEVVPKATQ KEAVAFLNRQ VFATPTWLIN PAILNKINIE TGVEAIKSIQ ESTLNNLLAG
DRAARLMETG STNSANYNLD ELMTDLRGGI WAELKTRKAI DVYRRNLQKV YVEKVISLLN
PTSTMLMTVP PGVTYGYETR IVDLKKTDLP SIARANLESL KAEIKAALPL TTDKMSKYHL
QDVLSRIEKA LDPK
//
