ID A0A2N4XEF8_9BACT Unreviewed; 985 AA.
AC A0A2N4XEF8;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=type I site-specific deoxyribonuclease {ECO:0000256|ARBA:ARBA00012654};
DE EC=3.1.21.3 {ECO:0000256|ARBA:ARBA00012654};
GN ORFNames=C0V77_10250 {ECO:0000313|EMBL:PLK44811.1};
OS Emticicia sp. TH156.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Spirosomataceae;
OC Emticicia.
OX NCBI_TaxID=2067454 {ECO:0000313|EMBL:PLK44811.1, ECO:0000313|Proteomes:UP000234203};
RN [1] {ECO:0000313|EMBL:PLK44811.1, ECO:0000313|Proteomes:UP000234203}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TH156 {ECO:0000313|EMBL:PLK44811.1,
RC ECO:0000313|Proteomes:UP000234203};
RA Cai h.;
RT "genomes of bacteria within cyanobacterial aggregates.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage of DNA to give random double-stranded
CC fragments with terminal 5'-phosphates, ATP is simultaneously
CC hydrolyzed.; EC=3.1.21.3; Evidence={ECO:0000256|ARBA:ARBA00000851};
CC -!- SIMILARITY: Belongs to the HsdR family.
CC {ECO:0000256|ARBA:ARBA00008598}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLK44811.1}.
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DR EMBL; PKRS01000004; PLK44811.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N4XEF8; -.
DR OrthoDB; 9758243at2; -.
DR Proteomes; UP000234203; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009035; F:type I site-specific deoxyribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR CDD; cd22332; HsdR_N; 1.
DR Gene3D; 3.90.1570.50; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR007409; Restrct_endonuc_type1_HsdR_N.
DR InterPro; IPR040980; SWI2_SNF2.
DR PANTHER; PTHR42927; HELICASE SUPERFAMILY 1 AND 2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR42927:SF1; HELICASE SUPERFAMILY 1 AND 2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF04313; HSDR_N; 1.
DR Pfam; PF18766; SWI2_SNF2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000313|EMBL:PLK44811.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000234203};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747}.
FT DOMAIN 293..490
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REGION 619..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 985 AA; 114615 MW; E3306783855C91F1 CRC64;
MTEKRFEEYI EKYLTSTDDN GLVYTALHFS NYDRTLCLLP AEVLAFLQSS QPEAYQRWQV
QFGEKADEKL LQRLSTQIEK DGLIKVLREG IRDRGVYFDM TYFEPKSGLN PEHQAKYLCN
RLSIVRQLHY SKANEKSIDM VLFINGIPII GIELKNQLSG QDISHASRQY QFDRDPKNEP
LLQFKRMLVH FIVDNDTVGM ASKLDGADTR FLPYNRDIVN PIVANDYKVS YLWKEVLSPN
SVLDIIENFV LETTETEKEW DEKLGRVVEK KKDLLIFPRY HQLDVIRKLK TQIKAEGAGH
YYLIQHTTGS GKSYSIGWLA HTLTSLYQNS SQKTRLFDTI VVVTDRKVLD KQLQKTLRDL
EQTAGVVKAI DKNSEQLKEA LAKGNDIVVT TIQKFGVIAD AMSKLKGRTF GVIIDEVHSS
QTGETAKKLK KSLSFNEFEE DEEEDYEDIM TKEILSRGRQ KHISFFGFTG TPKNKTLELF
GRKNEFGQFV PFHSYSMKQS IFEGYTLDVL AHYMPYKRWF RLKQEDGKDD LELPEGKVKR
ELMNFVDSHP ETIRQKVAII LNQFIHHTQK QIRGKARAMV VVRSRKHCVL YQQEMLKQMK
ALRLPFSCLV AFSGSIQKDG KEHTEGSLNT ENGLQGGVSI PDGLKDPRFR ILIVSNKYQT
GFDEPLIHTM FVDKRLGGVQ CVQTLSRLNR KATGKTDTFV LDFVNEPEEI IEAFQPFYTS
TILTGETDSY KLYELDSEIK SFHLFTKYEL DEFCQLFFSE RKSDEAFQPY LNRAVEKWQE
IEPTDKREEY RSLINAYCRL YSYISQIMDF QDAELEKLFI FLKYLKKKLP KRIGTTVDIT
DAIDLESLRL QKQEEMKLKL DDKEGELDPM AESGAKGKDA EENSLLSEII RKVNEVHGVN
LKEEDRIRLF NGLKNVYVRM SQSAEIRKVM EGDNSEANKW QYWNEMMSKI FLEYINDNFD
FYKTVESPGI KPIIVDLMYR QYMRM
//
