ID A0A2N4XMW4_9RHOO Unreviewed; 1146 AA.
AC A0A2N4XMW4;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969,
GN ECO:0000313|EMBL:PLK48238.1};
GN ORFNames=C0V76_13500 {ECO:0000313|EMBL:PLK48238.1};
OS Uliginosibacterium sp. TH139.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales; Zoogloeaceae;
OC Uliginosibacterium.
OX NCBI_TaxID=2067453 {ECO:0000313|EMBL:PLK48238.1, ECO:0000313|Proteomes:UP000234247};
RN [1] {ECO:0000313|EMBL:PLK48238.1, ECO:0000313|Proteomes:UP000234247}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TH139 {ECO:0000313|EMBL:PLK48238.1,
RC ECO:0000313|Proteomes:UP000234247};
RA Cai h.;
RT "genomes of bacteria within cyanobacterial aggregates.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLK48238.1}.
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DR EMBL; PKRR01000005; PLK48238.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N4XMW4; -.
DR InParanoid; A0A2N4XMW4; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000234247; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11140; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR048635; MFD_D3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21132; MFD_D3; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000234247}.
FT DOMAIN 618..779
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 800..954
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1146 AA; 127476 MW; 85885C3574386D20 CRC64;
MSSPALPPLQ PLAAFSLPKP GQRFDLPRLH GSADAAALAQ LAASGQKLIV ITANPLDAQR
LVEEIAWFAQ GLRVHLLPDW ETLPYDNFSP HQDLISERLA TLYAIHKGES DITLLPATTA
LYRMAPPQYL AGHTFFMKAK QVLDVEAFKL QMALAGYEHV TQVVRPGEFS VRGGLIDLFP
MGVKLPYRID LFDDEIDTIR TFDPDTQRTV YPVPEIRLLP AREFPMDDKG RSHFRAAFRE
AFEGDPTKSP IYKDVSNGVA SAGIEYYLPL FFDATASLFD YLPKNVLLVT HQDVPAAIEA
FWVEANSRYR LMAGDRARPL LPPEQLFLPA EAFWLAAKGL PRVAMGEKNE GHALSSALPD
LGVERKASDP LHKLKHYLAN FPWRVLVLAE SAGRAQTITE YFHEYDLKPA ASADLAGFLA
TDARLGLASG PLSAGFVLPG ANIAILTENE LYAAQARPRG RGRDARKSTV EGWLKDLSEL
KIGDPVVHQS HGIGRYLGLV HMDMGEGDTE FLHLEYAEDT KLYVPVSQLH VITRYAGADP
ENIALHKLGS GQWEKAKRKA AQQVRDTAAE LLVLYAKRAA RPGHKFDFKQ HDLEAFAEGF
GFEETPDQLA AINAVVDDMR SGRPMDRLVC GDVGFGKTEV ALRATFIAVA DGKQVAVLCP
TTLLAEQHYQ TFADRFADWP IKVAEISRFK TAKEQAEAIE MLAQGKVDIL IGTHRLLQKD
VEFKRLGLVI IDEEHRFGVR QKEALKNLRS EVDILTLTAT PIPRTLGMAM EGLREFSVIA
TAPQKRLAIK TFVQGWSKGI VREAVLREFK RGGQVYFLHN EVDTIENMRN TLTELLPEAR
IVVGHGQMNE RELERVMKDF TAQRANLLLC TTIIETGINI PTANTIVINR ADRFGLAQLH
QLRGRVGRSH HQAYAYLLTD ANAKPSANAQ KRLEAITMME DLGSGFFLAM HDLEIRGAGE
VLGDNQSGEI QQVGFAMYSQ MLNRAVKALQ NGKEVDLAQP LDVTSEINLH APALLPNAYC
PDVQERLTLY KRMANCEDVD ELQAIQEELI DRFGELPAQG QALLETHRLR IAAKPLGIIK
IDASEGRIHL HFEPNPPIEP IKIIKLIQNN RNWKLAGQDK LTISITADTF AERVNKVRNC
LKQLSA
//
