ID   A0A2N5G5U1_9BACI        Unreviewed;       764 AA.
AC   A0A2N5G5U1;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Pyruvate synthase {ECO:0000313|EMBL:PLR76109.1};
GN   ORFNames=CU633_17695 {ECO:0000313|EMBL:PLR76109.1};
OS   Bacillus sp. V3-13.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=2053728 {ECO:0000313|EMBL:PLR76109.1, ECO:0000313|Proteomes:UP000234805};
RN   [1] {ECO:0000313|EMBL:PLR76109.1, ECO:0000313|Proteomes:UP000234805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=V3-13 {ECO:0000313|EMBL:PLR76109.1,
RC   ECO:0000313|Proteomes:UP000234805};
RA   Seuylemezian A., Cooper K., Vaishampayan P.;
RT   "Comparitive Functional Genomics of Dry Heat Resistant strains isolated
RT   from the Viking Spacecraft.";
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PLR76109.1}.
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DR   EMBL; PGUZ01000053; PLR76109.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2N5G5U1; -.
DR   OrthoDB; 9794954at2; -.
DR   Proteomes; UP000234805; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 3.
DR   InterPro; IPR033412; PFOR_II.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   PANTHER; PTHR32154; PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED; 1.
DR   PANTHER; PTHR32154:SF0; PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED; 1.
DR   Pfam; PF17147; PFOR_II; 1.
DR   Pfam; PF01855; POR_N; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Electron transport {ECO:0000256|ARBA:ARBA00022982};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Pyruvate {ECO:0000313|EMBL:PLR76109.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000234805};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          30..255
FT                   /note="Pyruvate flavodoxin/ferredoxin oxidoreductase
FT                   pyrimidine binding"
FT                   /evidence="ECO:0000259|Pfam:PF01855"
FT   DOMAIN          278..382
FT                   /note="Pyruvate:ferredoxin oxidoreductase core"
FT                   /evidence="ECO:0000259|Pfam:PF17147"
FT   DOMAIN          495..652
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   764 AA;  84470 MW;  9626184E1B2FC6D9 CRC64;
     MAIMEQNLKQ SGTAEQLTTF ESGNEMAAMA AAQINYHIMG YFPITPSTEV AQYLDQMKAR
     GEHDIQLIAA DGEHGSAGIC YGAAVTGARV FNATSANGFM YMLEQLPVQS GTRFPMVMNL
     VTRSISGPLD IRGDHSDLYF ALNTGWVILT ARTPQAVYDM NIMALKIAEH SDVRLPVIVA
     YDGFFTSHQK RKVQYFKDRK TVQQFVGECP DSYHFARDPK KPVTIGAHMN GDDLLNNHFQ
     QSEAMYRAGA VYEKVAAEYA RLSGRKYSAL DLYKMEDAEV ALFLLNSAAE SAKDTVDKLR
     KQGIKAGVIS PNIIRPFPAA EIREALKGVK ALLVGERADS YGANGPNLTH EVKSALQEDQ
     DNNTIVLSRV FGLGGKDFYP DDAEQFFRFA IDAIENGKAE KPFDYYGHVP GDPQKILQPV
     ISPQHSDAYK SGLIEVKKDE ATNKLKVKIP PLRALTAKPK RLASGHGACP GCGIFGGLEL
     FFKGIEGDVV VLFQTGCAYV VTTAYPYTSH KQTMIHNLFQ NGAATLSGTV EAFLELKRRG
     EISVSDDATF VMITGDGGMD IGMGSAIGTA LRNHKLIMLE YDNEGYMNTG SQMSYSTPLG
     HMTSTSNVGK SQKGKAFHHK DTAQIMAAAN IPYVFTGTEA FPQDLIKKAA KAQWYAQNVG
     TVYGKILITC PLNWKSDDRL GEKIVEAAVN SCFFPLYEVE EGMTTITYDP EKKNKRIPLS
     EWLKLMGKTK HLLKEENKQL LADFEEEVEK RWQRLCARHE NHLL
//