ID A0A2N5G8Z9_9BACI Unreviewed; 721 AA.
AC A0A2N5G8Z9;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=CU633_11775 {ECO:0000313|EMBL:PLR77216.1};
OS Bacillus sp. V3-13.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=2053728 {ECO:0000313|EMBL:PLR77216.1, ECO:0000313|Proteomes:UP000234805};
RN [1] {ECO:0000313|EMBL:PLR77216.1, ECO:0000313|Proteomes:UP000234805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=V3-13 {ECO:0000313|EMBL:PLR77216.1,
RC ECO:0000313|Proteomes:UP000234805};
RA Seuylemezian A., Cooper K., Vaishampayan P.;
RT "Comparitive Functional Genomics of Dry Heat Resistant strains isolated
RT from the Viking Spacecraft.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLR77216.1}.
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DR EMBL; PGUZ01000029; PLR77216.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N5G8Z9; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000234805; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR025589; Toprim_C_rpt.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR Pfam; PF13342; Toprim_Crpt; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:PLR77216.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000234805};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..140
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 721 AA; 81175 MW; 4AE74E3E576595C9 CRC64;
MKLIIAEKPD QGATLASVFK NKKQQGYIEI YPNQIFPEGA FVTWAIGHLC QLSAPEKYKP
EWKKWSLQTL PIVPDQFTYE VTKDKGKQFA VIKKLISKPE VSEIIHAGDA GREGELIIRN
ILRLTKCKKP MKRLWISSLT PNSIKQGFQS LLGEEETRNL YYEAYTRACA DWVVGMNASR
LYSLLLQKNG FSDVFSVGRV QTPTLALIVQ REHEIDSFVS EPFWEVQAKF DIDGKKYEGK
WGKDGETRIK TKELAEKIAA FCQEKPAEVA DVHSEKKEFL PPLLYNLSAL QADANRRFKF
SPKKTLDVLQ KLYQRGIVSY PRSDSRHVTK GEAEAFPGIL SKLAKLPGYE GLFPLPHSSI
ATDKRYVNDK KVTDHYAIIP TDQVPNTDRL SGDEQKLYDL VARSLVAAHY PKAVTEYTTV
KTVVDGRAEF VSKGKVQLEE GWRKVLPQKE KEEEPLLPSL QAGEKGAVIK AEVKESRTQP
PKRYTEGQLI TLMKTAGKHI EDKELEKVLM KTEGLGTEAT RAGIITMLKD RNYIEIKKNL
VYATAKAKIL IGAIGAQVLA SPEMTARWEQ RLKEISEGKA SPKQFMDQTG KMVAHLISAA
VEEAADWSFK SEETEGFIPR KQKQKRVTKL GKCRKCDGQV IDKGSFFGCT NYNNTGCNFT
LSKKIAGKTI TQKIAKTLLE QGTTDTIEGF KGKDKLFNAK LTWDANGDKI IFLFEKSHSG
M
//