ID   A0A2N5GZA9_9BACI        Unreviewed;       136 AA.
AC   A0A2N5GZA9;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Alkyl hydroperoxide reductase {ECO:0000313|EMBL:PLR96098.1};
GN   ORFNames=CVD19_12370 {ECO:0000313|EMBL:PLR96098.1};
OS   Bacillus sp. T33-2.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=2054168 {ECO:0000313|EMBL:PLR96098.1, ECO:0000313|Proteomes:UP000235118};
RN   [1] {ECO:0000313|EMBL:PLR96098.1, ECO:0000313|Proteomes:UP000235118}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T33-2 {ECO:0000313|EMBL:PLR96098.1,
RC   ECO:0000313|Proteomes:UP000235118};
RA   Seuylemezian A., Cooper K., Vaishampayan P.;
RT   "Comparitive Functional Genomics of Dry Heat Resistant strains isolated
RT   from the Viking Spacecraft.";
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of
CC       hydrogen peroxide and organic hydroperoxides to water and alcohols,
CC       respectively. Plays a role in cell protection against oxidative stress
CC       by detoxifying peroxides. {ECO:0000256|ARBA:ARBA00037420}.
CC   -!- SIMILARITY: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
CC       {ECO:0000256|ARBA:ARBA00009796}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PLR96098.1}.
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DR   EMBL; PGVB01000015; PLR96098.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2N5GZA9; -.
DR   OrthoDB; 9812811at2; -.
DR   Proteomes; UP000235118; Unassembled WGS sequence.
DR   GO; GO:0102039; F:NADH-dependent peroxiredoxin activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR   InterPro; IPR000866; AhpC/TSA.
DR   InterPro; IPR024706; Peroxiredoxin_AhpC-typ.
DR   InterPro; IPR019479; Peroxiredoxin_C.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR10681; THIOREDOXIN PEROXIDASE; 1.
DR   PANTHER; PTHR10681:SF128; THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL; 1.
DR   Pfam; PF10417; 1-cysPrx_C; 1.
DR   Pfam; PF00578; AhpC-TSA; 1.
DR   PIRSF; PIRSF000239; AHPC; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000235118}.
FT   DOMAIN          2..83
FT                   /note="Alkyl hydroperoxide reductase subunit C/ Thiol
FT                   specific antioxidant"
FT                   /evidence="ECO:0000259|Pfam:PF00578"
FT   DOMAIN          105..129
FT                   /note="Peroxiredoxin C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF10417"
FT   REGION          113..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   136 AA;  14822 MW;  03B01F8FD2B44DC9 CRC64;
     MAAVAAIYPF IKAMDAELLA ISTDSVYSHV VFKETSPSLK HVTYPMLSDR NHGISKAYRV
     LDSSTGASYR ASFFINPGQI IKAKLVYAAE VGRNIPEHLR ILQGFHHAEQ TGQDVPANWV
     PGQPGISQDP SKIGTI
//