ID A0A2N5GZA9_9BACI Unreviewed; 136 AA.
AC A0A2N5GZA9;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Alkyl hydroperoxide reductase {ECO:0000313|EMBL:PLR96098.1};
GN ORFNames=CVD19_12370 {ECO:0000313|EMBL:PLR96098.1};
OS Bacillus sp. T33-2.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=2054168 {ECO:0000313|EMBL:PLR96098.1, ECO:0000313|Proteomes:UP000235118};
RN [1] {ECO:0000313|EMBL:PLR96098.1, ECO:0000313|Proteomes:UP000235118}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T33-2 {ECO:0000313|EMBL:PLR96098.1,
RC ECO:0000313|Proteomes:UP000235118};
RA Seuylemezian A., Cooper K., Vaishampayan P.;
RT "Comparitive Functional Genomics of Dry Heat Resistant strains isolated
RT from the Viking Spacecraft.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of
CC hydrogen peroxide and organic hydroperoxides to water and alcohols,
CC respectively. Plays a role in cell protection against oxidative stress
CC by detoxifying peroxides. {ECO:0000256|ARBA:ARBA00037420}.
CC -!- SIMILARITY: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
CC {ECO:0000256|ARBA:ARBA00009796}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLR96098.1}.
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DR EMBL; PGVB01000015; PLR96098.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N5GZA9; -.
DR OrthoDB; 9812811at2; -.
DR Proteomes; UP000235118; Unassembled WGS sequence.
DR GO; GO:0102039; F:NADH-dependent peroxiredoxin activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR000866; AhpC/TSA.
DR InterPro; IPR024706; Peroxiredoxin_AhpC-typ.
DR InterPro; IPR019479; Peroxiredoxin_C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR10681; THIOREDOXIN PEROXIDASE; 1.
DR PANTHER; PTHR10681:SF128; THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL; 1.
DR Pfam; PF10417; 1-cysPrx_C; 1.
DR Pfam; PF00578; AhpC-TSA; 1.
DR PIRSF; PIRSF000239; AHPC; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000235118}.
FT DOMAIN 2..83
FT /note="Alkyl hydroperoxide reductase subunit C/ Thiol
FT specific antioxidant"
FT /evidence="ECO:0000259|Pfam:PF00578"
FT DOMAIN 105..129
FT /note="Peroxiredoxin C-terminal"
FT /evidence="ECO:0000259|Pfam:PF10417"
FT REGION 113..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 136 AA; 14822 MW; 03B01F8FD2B44DC9 CRC64;
MAAVAAIYPF IKAMDAELLA ISTDSVYSHV VFKETSPSLK HVTYPMLSDR NHGISKAYRV
LDSSTGASYR ASFFINPGQI IKAKLVYAAE VGRNIPEHLR ILQGFHHAEQ TGQDVPANWV
PGQPGISQDP SKIGTI
//