ID A0A2N5H022_9BACI Unreviewed; 382 AA.
AC A0A2N5H022;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE RecName: Full=UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) {ECO:0000256|ARBA:ARBA00038858};
DE EC=5.1.3.14 {ECO:0000256|ARBA:ARBA00038858};
GN ORFNames=CVD19_11600 {ECO:0000313|EMBL:PLR96622.1};
OS Bacillus sp. T33-2.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=2054168 {ECO:0000313|EMBL:PLR96622.1, ECO:0000313|Proteomes:UP000235118};
RN [1] {ECO:0000313|EMBL:PLR96622.1, ECO:0000313|Proteomes:UP000235118}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T33-2 {ECO:0000313|EMBL:PLR96622.1,
RC ECO:0000313|Proteomes:UP000235118};
RA Seuylemezian A., Cooper K., Vaishampayan P.;
RT "Comparitive Functional Genomics of Dry Heat Resistant strains isolated
RT from the Viking Spacecraft.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-
CC mannosamine; Xref=Rhea:RHEA:17213, ChEBI:CHEBI:57705,
CC ChEBI:CHEBI:68623; EC=5.1.3.14;
CC Evidence={ECO:0000256|ARBA:ARBA00036080};
CC -!- SIMILARITY: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
CC {ECO:0000256|ARBA:ARBA00038209, ECO:0000256|RuleBase:RU003513}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLR96622.1}.
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DR EMBL; PGVB01000013; PLR96622.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N5H022; -.
DR OrthoDB; 9803238at2; -.
DR Proteomes; UP000235118; Unassembled WGS sequence.
DR GO; GO:0008761; F:UDP-N-acetylglucosamine 2-epimerase activity; IEA:InterPro.
DR CDD; cd03786; GTB_UDP-GlcNAc_2-Epimerase; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR003331; UDP_GlcNAc_Epimerase_2_dom.
DR InterPro; IPR029767; WecB-like.
DR NCBIfam; TIGR00236; wecB; 1.
DR PANTHER; PTHR43174; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR PANTHER; PTHR43174:SF2; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR Pfam; PF02350; Epimerase_2; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU003513};
KW Reference proteome {ECO:0000313|Proteomes:UP000235118}.
FT DOMAIN 28..365
FT /note="UDP-N-acetylglucosamine 2-epimerase"
FT /evidence="ECO:0000259|Pfam:PF02350"
SQ SEQUENCE 382 AA; 43161 MW; 97E87D0BB6EDEC56 CRC64;
MKQPIKVMTI FGTRPEAIKM APLVLELQKQ PEHFESIVTV TAQHRQMLDQ VLDIFKITPD
YDLNIMKDRQ TLVDVTTRGL EGLDRVMKEV KPDIVLVHGD TTTTFVASLA ALYNQITVGH
VEAGLRTWNK YSPFPEEMNR QLTGVMADLH FAPTAMAADN LLRENKSQEN IFITGNTAID
ALKTTVKETY HHEVLDKVGD DRLILLTAHR RENLGDPMRN MFRAIKRIVD EQPDVQVVYP
VHLNPVVREI ASEILGNDPR IHLIEPLDVI DFHNFASRAF LILTDSGGVQ EEAPSLGVPV
LVLRDTTERP EGIEAGTLKL AGNQEEPIYE MATELLNSRE AYEKMAGAVN PYGDGLASKR
IADAIRYYFK QLDDRPREYQ PK
//
