ID A0A2N5WWJ7_9ACTN Unreviewed; 463 AA.
AC A0A2N5WWJ7;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Two-component sensor histidine kinase {ECO:0000313|EMBL:PLW66600.1};
GN ORFNames=C0036_21990 {ECO:0000313|EMBL:PLW66600.1};
OS Streptomyces sp. DJ.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2067551 {ECO:0000313|EMBL:PLW66600.1, ECO:0000313|Proteomes:UP000235150};
RN [1] {ECO:0000313|EMBL:PLW66600.1, ECO:0000313|Proteomes:UP000235150}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DJ {ECO:0000313|EMBL:PLW66600.1,
RC ECO:0000313|Proteomes:UP000235150};
RA Ke Y., Yu G., Ye J., Yuan X.;
RT "Genome of Streptomyces sp. DJ strain.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLW66600.1}.
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DR EMBL; PKSK01001651; PLW66600.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N5WWJ7; -.
DR Proteomes; UP000235150; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF10; SENSORY TRANSDUCTION HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:PLW66600.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000235150};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 45..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 217..282
FT /note="Signal transduction histidine kinase subgroup 3
FT dimerisation and phosphoacceptor"
FT /evidence="ECO:0000259|Pfam:PF07730"
FT DOMAIN 331..422
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|Pfam:PF02518"
FT REGION 429..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 463 AA; 48414 MW; 49A796EE854D0182 CRC64;
MAQGAWAGLK QDLFTSVLDF RPLPPLRLDS VPMARSLPGA LRDRLKWLPH AAVVTFAGLV
LLVDVREGPG GVAGLFYLLG HSLVLFAALL MTLFRPVTAW WLSGLAGLTG MFAGAGIGSW
PWSAAGFVTH LAVMVLVAMR SRPRVAVEMW VVTLVVGSAV DVLIGYGGST AAPMAVFSGV
ALLTTVTVCG WWRTRERVVV QETITAQERS RRTVLEERAT IARELHDVVA HHMSVIAIQA
EAAPYRVEEA PAELVKSFAV IRENAVAALT ELRRVLGVVR SETPHPFADE GPEAPQPTLA
NLGSLLDNVR AAGLDVDSVV TGSVRPLPQG VELSAYRIVQ EALSNALRHA PGATAVVEVS
YVLGGLGLRV VNGPPSEAAR PSPGAGHGVL GMQERVAMLG GEMNAQPTPD GGYEVAVFVP
VAAPEPSAAS AASASSASSE APTVAVPAVT DGRGVNLFKE GSA
//
