ID   A0A2N5X4T6_9GAMM        Unreviewed;       758 AA.
AC   A0A2N5X4T6;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   SubName: Full=DNA internalization-related competence protein ComEC/Rec2 {ECO:0000313|EMBL:PLW69507.1};
GN   ORFNames=C0039_08265 {ECO:0000313|EMBL:PLW69507.1};
OS   Pseudohalioglobus lutimaris.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales; Halieaceae;
OC   Pseudohalioglobus.
OX   NCBI_TaxID=1737061 {ECO:0000313|EMBL:PLW69507.1, ECO:0000313|Proteomes:UP000235005};
RN   [1] {ECO:0000313|EMBL:PLW69507.1, ECO:0000313|Proteomes:UP000235005}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HF004 {ECO:0000313|EMBL:PLW69507.1,
RC   ECO:0000313|Proteomes:UP000235005};
RA   Du Z.-J., Shi M.-J.;
RT   "The draft genome sequence of Halioglobus lutimaris HF004.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PLW69507.1}.
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DR   EMBL; PKUS01000007; PLW69507.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2N5X4T6; -.
DR   OrthoDB; 9761531at2; -.
DR   Proteomes; UP000235005; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR   CDD; cd07731; ComA-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR035681; ComA-like_MBL.
DR   InterPro; IPR004477; ComEC_N.
DR   InterPro; IPR004797; Competence_ComEC/Rec2.
DR   InterPro; IPR025405; DUF4131.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   NCBIfam; TIGR00360; ComEC_N-term; 1.
DR   NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR   PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR   PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR   Pfam; PF03772; Competence; 1.
DR   Pfam; PF13567; DUF4131; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000235005};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        24..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        239..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        289..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        325..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        378..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        405..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        460..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          520..703
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
SQ   SEQUENCE   758 AA;  81533 MW;  D19068CDFD7D8668 CRC64;
     MRAWMFGCLL GTLAAAFAPR LMSYWLVVCL ILIALGLLCV SRQWRALFTS SLLLTLAFTS
     LRGQDLLQTR LEPACNRQTL WLTGRVSSLP RKTRVRDGVS RQRFEFSVEN LLPAMCSGPR
     TVLLSYYGRE GLTPGERRQF EVTLRRPWGL ANPGSFNMQG WYTLSGIDAV GSVRGEGVLL
     QHAGTDAWNW HHRLRQSIAA GIDNAALPVA SAAVLKALTV ADKSGIDHQL WRLFQQFGLN
     HLLVISGLHV ALVAALAYLA GRLLRAALQL AVRSAANWPL PELGALSAAM GYAALAGFSV
     ATSRALVMLA CFLLARMTGR HSTGFNNLLL AATLLVTFNP MVVVGSGFWL SFGAVAGLLW
     LASWQARQSL MGKLWRPHLL MSLLMLPAGA LFFGGISWVS APANLLMVPL VGWIIVPLAL
     LGAVLSVAGN PLAAVLWRIA AWPVDWLLAP ALSLAEQQTL FLPVSADGFA LALSLLAVFL
     GLLPMQRRYR LVTLALFLPL LLPGRAADTT PRLSVLDAGQ GTAVVFSAGA RALLYDTGGG
     DPAGPNIANT VVIPWLRHSR LRSLQTLMVS HDDLDHSAGV VDVQRAMPVV SLLVGETLLP
     GARACRAGMS WEWPAGIRFQ VLSPGAAEEG NDASCVLLID APGMRVLLAG DIGVEQEREL
     IRFWGPQLTS DVLLVGHHGS STSTSQSWLN HVSPRIAVIS AGYASRFGHP HADVLARLHT
     QGIAVRETAL EGALTIEAGA DGALRVSAHR GGYQPWWM
//