ID A0A2N5XJE5_9ACTN Unreviewed; 628 AA.
AC A0A2N5XJE5;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Propionyl-CoA synthetase {ECO:0000313|EMBL:PLW74626.1};
DE EC=6.2.1.17 {ECO:0000313|EMBL:PLW74626.1};
GN Name=prpE {ECO:0000313|EMBL:PLW74626.1};
GN Synonyms=yahU {ECO:0000313|EMBL:PLW74626.1};
GN ORFNames=C0036_00890 {ECO:0000313|EMBL:PLW74626.1};
OS Streptomyces sp. DJ.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2067551 {ECO:0000313|EMBL:PLW74626.1, ECO:0000313|Proteomes:UP000235150};
RN [1] {ECO:0000313|EMBL:PLW74626.1, ECO:0000313|Proteomes:UP000235150}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DJ {ECO:0000313|EMBL:PLW74626.1,
RC ECO:0000313|Proteomes:UP000235150};
RA Ke Y., Yu G., Ye J., Yuan X.;
RT "Genome of Streptomyces sp. DJ strain.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLW74626.1}.
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DR EMBL; PKSK01000070; PLW74626.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N5XJE5; -.
DR Proteomes; UP000235150; Unassembled WGS sequence.
DR GO; GO:0050218; F:propionate-CoA ligase activity; IEA:UniProtKB-EC.
DR CDD; cd05967; PrpE; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43347; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43347:SF3; ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:PLW74626.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000235150}.
FT DOMAIN 4..58
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 62..445
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 510..588
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 628 AA; 68329 MW; B5D699DA95CDD811 CRC64;
MDAYRRAYEQ SITDPEAFWG EAAEAVEWVR KPSRVLDSSR PPFHRWFPDG ELNTCHNALD
RHVAAGHGDR VALHYDSPVT DTRRSLTYAE LLEQTARFAG VLRGLGVERG DRVVIYMPMV
PQAVVAMLAC ARIGAVHSVV FGGFAPKELA VRIDDARPKV VVSASCGIEP GRTVHYKPML
DEALRLAEHT PDRCVILQRP QARADMGELD LDWDEAAAAA EPADCVPVAA TDPLYVLYTS
GTTGRPKGVV RDNGGHAVAL AWTMANTYDV GPGDVWWTAS DVGWVVGHSY IVYAPLLVGA
TTVLYEGKPV GTPDAGAFWR VISDYRVKAL FTAPTALRAV RKQDPEGEHT TRYDLSSLRC
LFMAGERLDP DTYAWASKVL GVPVIDNWWQ TETGWPIASN HRGLEPMPVK PGSPTVPSPG
YDLHVLDADG NECAPGEEGS IVLRLPLPPG TLPTLWNDDE RYVDSYLSRF PGHYLTGDSG
YVDEDGYVFV MGRTDDVINV AGHRLSTGSM EAVVASHPAV AECAVIGVHD PLKGQVPRAL
VVLKAGVTAD PDDLQGELVR MVREQIGPVA ALKEVAVVPA LPKTRSGKIL RRSMRLMADG
KEAAVPSTIE DPDVLEALRP VLRREPGQ
//
