ID A0A2N5XY60_9GAMM Unreviewed; 790 AA.
AC A0A2N5XY60;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN ORFNames=CWI75_17535 {ECO:0000313|EMBL:PLW81084.1};
OS Kineobactrum sediminis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales; Halieaceae;
OC Kineobactrum.
OX NCBI_TaxID=1905677 {ECO:0000313|EMBL:PLW81084.1, ECO:0000313|Proteomes:UP000234845};
RN [1] {ECO:0000313|Proteomes:UP000234845}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F02 {ECO:0000313|Proteomes:UP000234845};
RA Du Z.-J., Chang Y.-Q.;
RT "The draft genome sequence of Chromatocurvus sp. F02.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLW81084.1}.
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DR EMBL; PKLZ01000017; PLW81084.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N5XY60; -.
DR OrthoDB; 5807460at2; -.
DR Proteomes; UP000234845; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd05784; DNA_polB_II_exo; 1.
DR CDD; cd05537; POLBc_Pol_II; 1.
DR Gene3D; 2.40.50.590; -; 1.
DR Gene3D; 3.30.70.2250; -; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR Pfam; PF21474; DNApolII_N; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Reference proteome {ECO:0000313|Proteomes:UP000234845};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT DOMAIN 87..308
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 389..744
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 790 AA; 87881 MW; 5B23931F54A5ABB2 CRC64;
MKPSLNPGSA YREGFLLSRS WRDDSAGIVL EFWFATAQGP VQVVIYGERS VFFLAESDAS
RYQSVLALQH GISCKPLTLR DFSMSPVTAI YSQGYQQARQ LADGLRQRGA EPLEADINPA
DRYLMERFIA GGASLCGPIT DCGAYQRMVN PALRSAAFRP ALKVVSFDIE TAMAGLQLYS
IAVHATGDDG EHRRVFIVGE GVFGDHVQGL PSQQEVLQAF LAFIADYDPD VLIGWNVVNF
DTWYLQRLAD QLGVPLNLGR AGSVVHWREL DEDGQRRAAR IPGRVLLDGI ELLRAAFYRF
DSFSLEAVAR SLLDEGKLLH GSDRGEEIGR LFREDKARLA AYNLRDCELV SAIFAKTRLL
DFALARSAMT GLNLDRLGGS VASFDNLYLP RLHRKGFVAP NARESGVASP GGFVLDSRPG
IYDHVLVLDF KSLYPSIIRT FAIDPLGLAL GMTGELEESA TVPGFLGAHF AREGHILPAL
ISQLWQQRDA AREADDSPLS QAIKIIMNSF YGVLGSPGCR FFDSRLATAI TRRGHEILLR
TRERIESRGH QVIYGDTDSV FVWIENAVCD ADAERAGLAL QADLNTWWQH QLQEAFGLES
LLELQFETHY RRFLMPTVRG SDKGSKKRYA GLVGTGAAER LVFKGLESVR TDWTRLAREF
QETLYRRVFL AEPYEDYLCQ VMGAVLAGER DADLVYRKRL RRRLDDYQRN VPPHVQAARL
YAERGLPLPA RGDWIEYVVT VAGAEPAAAA HAPLDYPHYV ERQVQPVADG ILGLLGTSFS
AITGRQIDLF
//
