ID A0A2N6NL10_BEABA Unreviewed; 1136 AA.
AC A0A2N6NL10;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Sterol regulatory element-binding protein cleavage-activating protein {ECO:0000256|ARBA:ARBA00019541};
GN Name=SCAP {ECO:0000313|EMBL:PMB67963.1};
GN ORFNames=BM221_006139 {ECO:0000313|EMBL:PMB67963.1};
OS Beauveria bassiana (White muscardine disease fungus) (Tritirachium
OS shiotae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX NCBI_TaxID=176275 {ECO:0000313|EMBL:PMB67963.1, ECO:0000313|Proteomes:UP000235728};
RN [1] {ECO:0000313|EMBL:PMB67963.1, ECO:0000313|Proteomes:UP000235728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEF-007 {ECO:0000313|EMBL:PMB67963.1,
RC ECO:0000313|Proteomes:UP000235728};
RX PubMed=27470140; DOI=10.1007/s00253-016-7734-y;
RA Kim S., Lee S.J., Nai Y.S., Yu J.S., Lee M.R., Yang Y.T., Kim J.S.;
RT "Characterization of T-DNA insertion mutants with decreased virulence in
RT the entomopathogenic fungus Beauveria bassiana JEF-007.";
RL Appl. Microbiol. Biotechnol. 100:8889-8900(2016).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004557}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004557}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the WD repeat SCAP family.
CC {ECO:0000256|ARBA:ARBA00007410}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PMB67963.1}.
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DR EMBL; MRVG01000006; PMB67963.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N6NL10; -.
DR OMA; EFQFRPM; -.
DR Proteomes; UP000235728; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0032933; P:SREBP signaling pathway; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR030225; SCAP.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46378; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR46378:SF1; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50156; SSD; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000235728};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT TRANSMEM 39..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 286..444
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REPEAT 659..699
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1018..1039
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1101..1136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1108..1128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1136 AA; 124994 MW; F7C07BC74CC9A5FB CRC64;
MIWYLLYPLR GTTEAPALSP SNPVRVAFTR YGNYVSQHVI LALLISGIVA TILIYPIPYL
FTDDFTNGAS NLPHHVWTVA QPLARDAAVL PDIIMRSIWV HGDYMQALDN HLLSAALELQ
DELLGPTENF FPAASQGFPP PSDDHWPMPT ESRDAVHIVN GLTNQSWFFH SPLLYWHCSR
QQILADTDII TTVNERKTQS TSANVTLRHS IVFSGKRFSE RRLLAADALV ITLLHLRDSP
VGRQWEHNAP LLTRKVKDKW DIYPTDGIVE SSQVYEFQFR PISIYDIISL ALAYGLMFIY
FLASLKKLRA IKSKAGLTAT VITQILLSIM SSFTVCAILD IDLSRIPRAA YPLVILAISL
ENMFRVIYAV ILSPAENSSS SRVGSAFGQT AHIALASIIQ NVAILVGLSM IVSPGVAGFC
IFAAIATVFD YFYLSTFFLC VLSVDVRRIE LEDELLKAST RRHNHTYGQL KERPSWIYNV
LRGKVALSTR IAGTVVMIGF VIIAQWHFFE GVGVLEPGKQ LFGTSTLQSP VAKEAASSLK
DIHQARSPGS WLRLQDHETA QEVINAIKPS AFSYTAQVYD PLVFVLKESN RTPPQQKKRL
LPAAYDFIDH QLAEFVISIA LVCACLRLLA SYLLMADEET RDNLSDSGES PSLSVKTLSG
GHVLDVAMMV ASSDGRIVSA GLDRTIRVWD IRSNVTSYEL PGTKLSDGRG LFPILGIAVD
AESKWLAIMS TSQIRLWNLS EYKWSDSIPM ESGSHNPEVF CFHPGSTLEI PRLVIVRKDG
TLTDVSMVGD NRRREAAVCD GQLLTARSLI HKGENLKVVN GFSPLLIVVG PESNTVRAMQ
ILSLSRNGEA FMSRETETGW RCESLPLNVV SDTTLHQIVP LSPHPLFLIG AISSVYLVSA
NDGVVQHVFA TEPVAWRSLQ CEYSDNRYNK SSSGIGFSSL TLGYVEANTQ ECIVTSYHPA
QGSEAIAAFA PSGGAGGGWC TWEEAIETKK RIRDPGTWEI IKERSVIGVR QEANPCRNTK
RADYRRRSAT ARGSPGAPTR WQAWTAATDG HLEADEVQSL LSDGAGSEEL VVVPTLGPKA
KIGVRSVAFS LGNTIKVISA GGPERYNADD DSTAESLLPK DNRRVRHGGG SMRGRG
//
