ID A0A2N6NPB3_BEABA Unreviewed; 1145 AA.
AC A0A2N6NPB3;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Phosphoinositide phospholipase C {ECO:0000256|ARBA:ARBA00012368, ECO:0000256|RuleBase:RU361133};
DE EC=3.1.4.11 {ECO:0000256|ARBA:ARBA00012368, ECO:0000256|RuleBase:RU361133};
GN Name=plc1_0 {ECO:0000313|EMBL:PMB69115.1};
GN ORFNames=BM221_005701 {ECO:0000313|EMBL:PMB69115.1};
OS Beauveria bassiana (White muscardine disease fungus) (Tritirachium
OS shiotae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX NCBI_TaxID=176275 {ECO:0000313|EMBL:PMB69115.1, ECO:0000313|Proteomes:UP000235728};
RN [1] {ECO:0000313|EMBL:PMB69115.1, ECO:0000313|Proteomes:UP000235728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEF-007 {ECO:0000313|EMBL:PMB69115.1,
RC ECO:0000313|Proteomes:UP000235728};
RX PubMed=27470140; DOI=10.1007/s00253-016-7734-y;
RA Kim S., Lee S.J., Nai Y.S., Yu J.S., Lee M.R., Yang Y.T., Kim J.S.;
RT "Characterization of T-DNA insertion mutants with decreased virulence in
RT the entomopathogenic fungus Beauveria bassiana JEF-007.";
RL Appl. Microbiol. Biotechnol. 100:8889-8900(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-
CC diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456,
CC ChEBI:CHEBI:203600; EC=3.1.4.11;
CC Evidence={ECO:0000256|RuleBase:RU361133};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PMB69115.1}.
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DR EMBL; MRVG01000005; PMB69115.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N6NPB3; -.
DR OMA; HWQREMS; -.
DR Proteomes; UP000235728; Unassembled WGS sequence.
DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd00275; C2_PLC_like; 1.
DR CDD; cd16207; EFh_ScPlc1p_like; 1.
DR CDD; cd13360; PH_PLC_fungal; 1.
DR CDD; cd08598; PI-PLC1c_yeast; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001192; PI-PLC_fam.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR037755; Plc1_PH.
DR InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR InterPro; IPR001711; PLipase_C_Pinositol-sp_Y.
DR PANTHER; PTHR10336:SF36; 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA PLC-3; 1.
DR PANTHER; PTHR10336; PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN; 1.
DR Pfam; PF00388; PI-PLC-X; 1.
DR Pfam; PF00387; PI-PLC-Y; 1.
DR PRINTS; PR00390; PHPHLIPASEC.
DR SMART; SM00239; C2; 1.
DR SMART; SM00148; PLCXc; 1.
DR SMART; SM00149; PLCYc; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
DR PROSITE; PS50008; PIPLC_Y_DOMAIN; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|RuleBase:RU361133};
KW Lipid degradation {ECO:0000256|RuleBase:RU361133};
KW Lipid metabolism {ECO:0000256|RuleBase:RU361133};
KW Reference proteome {ECO:0000313|Proteomes:UP000235728};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT DOMAIN 803..921
FT /note="PI-PLC Y-box"
FT /evidence="ECO:0000259|PROSITE:PS50008"
FT REGION 62..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1113..1145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1119..1145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1145 AA; 127836 MW; 23555FC9CCD690F7 CRC64;
MVMLYKTARP TPTTLPAKDM SNMSSLTAQL RRRPSPAMVQ TNVQPQHSNS LPISAISASS
IASSSRQASP TMSPDTAVLT TNSSLQPSPD AFHTRLDDDV CPPNFQLPDA IVSRKTSVNS
LAQSWTGNGS PLTEMPSNGP ASPTPAPTKT NLIRRLSSRA SRSITGRRRQ SSAAPPARDS
SVGPCFLRRR SDSNNGAPPD FAPANTDSES DFDDRDEYGS LRTNNFMLDG LVRDAPKPPA
RNATSPVGGS STTMAGPVIP LQLQQGVWLR KISKKSRSKR IRLQYDPDSN KLVWDKARPQ
KSLHVDEIRE IRTGSDIQQY GRDFKIPESE RSTWFSILYS VPERSKSKFM HLIADDTEAC
DVWTTFLHAM LRHRQEVMTS LMSFNDKAIA QYWQTEMAKQ PDFGGATQEL DLAGVKRVCQ
NLHIYSSPVI VHANFRIADA RARERLNFEE FLEFVRLMKQ RKDIRYIMHC NSANPEMGMT
LSEFLAFLRN VQGEDVEGNR AAWEKSFYRH ARKYRPESTS EGLEDLISED AFVAFLSSRH
NTPVADEPQD YTLDRPMNEY FISSSHNTYL LGRQVAGRSS IEGYIAALVR GCRCVEVDCW
DGPDGQPQVV HGRTLTTSIS FKEVMTTINK YAFVKSNFPL WISLEVHCNA VQQAIMAETI
KEAFGSRLVT EPLDPSSNKL PSPSELMGRI LIKVKEPRMH DDGNMSSAAV IAQATRGRGN
SVGSSSQPAH VSESPAPYIS QSLPQSPLLS GYPRRVASNS RKRVQTINEE TTHVRDMSSN
SDTESGSDTG SGSPSANKTI PVLGRLGVYC AGVKFPGFDT PAAKKFNHIF SFMESSFSKN
SRSKEDKMSL NIHNMRYLMR VYPDGTRLAS SNFDPLIYWR RGVQMAALNW QTFDLGMQLN
RAMFDGGQDS SGYVLKPPEL RDIQVLPYNS DIARGKKERS VVSFSVDMLS AQQLMRPANL
SASKSMDFYV EVEVFHANDK RDKKEGHFDG DNGTDTPLKF QTEVIRENGF SPMFMSGQFK
FKVVTKHPEL VFVRWSVKLS NDGESYSTKD RPPIASYTAK LRNLKEGFRT LPLLNHAGDQ
YLFSTLFCRI QIDEIEKTLI DAPRSPSDGS KLNRFGGKVF GRSNTSPRGT IEKTNVEKTS
FESYA
//
