ID A0A2N6NUJ8_BEABA Unreviewed; 3945 AA.
AC A0A2N6NUJ8;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Nonribosomal peptide synthetase 14 {ECO:0000313|EMBL:PMB70939.1};
GN Name=NRPS14_0 {ECO:0000313|EMBL:PMB70939.1};
GN ORFNames=BM221_003399 {ECO:0000313|EMBL:PMB70939.1};
OS Beauveria bassiana (White muscardine disease fungus) (Tritirachium
OS shiotae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX NCBI_TaxID=176275 {ECO:0000313|EMBL:PMB70939.1, ECO:0000313|Proteomes:UP000235728};
RN [1] {ECO:0000313|EMBL:PMB70939.1, ECO:0000313|Proteomes:UP000235728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEF-007 {ECO:0000313|EMBL:PMB70939.1,
RC ECO:0000313|Proteomes:UP000235728};
RX PubMed=27470140; DOI=10.1007/s00253-016-7734-y;
RA Kim S., Lee S.J., Nai Y.S., Yu J.S., Lee M.R., Yang Y.T., Kim J.S.;
RT "Characterization of T-DNA insertion mutants with decreased virulence in
RT the entomopathogenic fungus Beauveria bassiana JEF-007.";
RL Appl. Microbiol. Biotechnol. 100:8889-8900(2016).
CC -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC family. {ECO:0000256|ARBA:ARBA00029443}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PMB70939.1}.
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DR EMBL; MRVG01000003; PMB70939.1; -; Genomic_DNA.
DR OMA; QFFNIPP; -.
DR Proteomes; UP000235728; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd19532; C_PKS-NRPS; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF20; HYBRID PKS-NRPS SYNTHETASE APDA; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000235728};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..437
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2374..2449
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3513..3593
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2453..2510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2482..2510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3945 AA; 432449 MW; E9CBCC8A9D11F94A CRC64;
MSSHQNEPIA IIGNACRFPG DSTSPSKLWE LLKQPREVSR NIDRFQSAGF YNKDGHYHGA
SNVQHSYLLN EDPRLFDAQF FNIPPGEAES IDPQQRMILE TVYDAVETSG LVLENLRGSN
TAVYVGVMCD DYGNICYVDQ ESIPTYAATG TARSILSNRV SFIFDWRGPS MTIDTACSSS
LVALHQGVQV LRSGTSPIAI AAGANLIFSP NMFIAESNLN MLSPTGHSQM WDANADGYAR
GEGIAAVVMK RLSDAIRDGD NIECIIRETG VNQDGHTPGI TMPSQEAQTR LIHETYARAG
LDLSKPEDRP QYFEAHGTGT KAGDGVESKA IYKAFFPESD DKHDTLWVGS IKTIIGHTEG
TAGIAGVMKA SLAIQNKTIP PNMHFNTLNP EITPYYGKLQ IATAAQNWPK LASGSVPRAS
INSFGFGGTN AHAIIEAYVP EAPNALTQAA PAVANPLALT FSATSEKSLT NLMANYLEYL
TENSEVDIGK LAWTLHDRRS TFSYRSSVAA QTQDELVAKL QKSVEDQQSG NSSAVTRGTS
AKKNLLGVFT GQGAQWATMG RDLISSSKFA ESIIDKLEKS LGELPEGDRP SWSLKEQMMV
DPSKSRITEG ELSQPLCTAV QVMLVEMLKV AGIEFDSVVG HSSGEIGAAY ASGFISDTDA
IRIAYYRGRY AYLARGPEGQ RGGMLAAGTT LEDARELCDL PAFEGRVSAA AYNSSSSVTL
SGDLDAIEEV KEVLDDEKMF NRQLKVDTAY HSHHMIPCSQ KYYEALDACK INIMTPSGRT
KWYSSVYDGK VMEPCDALKH QYWVDNMVNI VLFATALSAA LSSSEPKLTQ AIEVGPHAAL
KGPASTVIEE TIKSTIPYTG TLSRGQNDVT AMATCLAYLW AQFGRSSADW KAYYGLFADS
TPKTMLNLPS YPFNHERLFW YEARKSRVNR LREDPAHVLL GTRTDTINER EIRWRNYIHS
GEIPWLQGHN IQGQTLFPAA GFLVMAVEAA RIAGRAEAIQ AIELKDSAIH RALAISEDKG
IETLFTLSNV TITETGEGTS VLTARFACDA CLQKQSDNFV SIASGDVIMT YGTPSSSALV
EYPKEEGLGM LDVDADLFYA YLANIGYNYA DMFKGITSLR RTTDLAQGVI TTKVPEALAN
EPIDQFLLHP STLDVAFQAI FAAISFPGDG ALWALHIPTT IRRVTINPVV CPMNGGVDEK
VRFSATSNRA DDGTFSGCVD IFPVHSDFSM CQVEGLEVSP VSPPTARDDR PFFGQTNHWL
SLPDADSFAA ALRITSTQEA EKSQLDRLAV SYLRNILQSS GHETDQLKSW AQTVLASLGK
KASLPAIEQS DVAVQDNSAY KTNFSILKTI GAGIEKGELP QGFDASELLN TFYETSLGAA
EAREALAILA QQIVRRYPHM NILDLSSGSG SVTKTVMDKI GALFSAYTCT GATDEHFAQL
SKDHPAISTR TIDFSEDLEE QGFFAGAYDL VIAGNGFHSI KDNVEGMQKL RSLVRPGGYL
LAQQITNSDS AHVGLTVASV ALQPEEISST TTLVADLGEY DDIFRTAGFS GIDTVTPDSA
SPFTVFVSQA IDQQILNIRE PLHSSKVDLE NVLIIGGQRF QVSRMIETMK KSLSPFAKNI
ETIRSLNDLD ASMLATRPYV VSLTELDDPF FENLTDTKWE ALKTLFFRSR YILWATQGAN
GDAPYANVMK GVVRCMLVEI PHLHGQMFNI EGQLKPEQHS LTIVESVMRL HISDTWKDKV
PTYDPLWTVE REYMLKDDKL WIMRYDSENT LNAGYNALRR RVIQEVSTKD QVVALTPEKQ
LQQYRLSPKA TVEIEGIPNS TVTVHQSLSS AIKVEGLGYM HLSVGKEAET GATVVAFSDK
NQSSLTLPKS RLLPVDVPEG KERSLLVAIA CNMLANDLLG KVTAGDRIVL HEPPTVLTKL
LAERVANTGV QLLFTTTRRK AALQAQWKHI HAYSTDRDMR QITAANTAIF VDFSNNEKRR
DVVEHLTEGL PFGTRKYELG DFLPSRSVLY SDSTEEQVST ALEKAYSTAT AERSSVPFDN
VANTRVQQLA DDADLAETLT TVDWTDATPF PASVTLAMDE VNFRPDRTYF LIGMTGSLGL
STCEYMMERG ARFFALSSRR PNVDKRWLEK VRKAYGAVVK AFPLDITSRA SLQKVHDDIN
DTMPPIAGVA NGALIMRDGL FMDSSAATMN EALGPKVAGS VFLDDLFYNV NLDFFILYSS
LVYVTGNIGQ TSYAAGNGFM VSLVHGRRAR GLNATVMNLG GISGIGYITR TDHGILGKLD
ILGYGIMSEL DYKYFFAESV MAGAADSGRN PEVSAGLRYV NKTEKNPPKW VVDPKFSHYV
IDRTSRDGGD KGGDSAMSTK AQLLEATTEK EAFNIILNAL MAMLGKKLDL PPTESVHSDV
AIVEMGVDSL VAVDLRSWFS NEFEHDIPVI KILGGATLAD LVEDTVANMS PDICPNISGG
SGDDAEAKPA PAAEAPIPVS AVDSSSGDSA SSSDERESAT SVETAPTTAS KVTKEVIAAP
KPIVDVAPKC HFVREEKMTH GCSRFWFLRQ YLEDSTCFNV LVQTRLNGKI DSARLQEAVR
KLGARHESLR TSFFVSEKGE PRMGVMSDSL LRLEVEKVQE ISQAEKAYKD MMGYNFDIER
GEVIRMRLLS LSETDHVFIF AVHHIAMDGF SFNLMIRDLD MMYQGKPVPQ IPAQFTDFAI
QQRRDVEAGR MRNDIAFWKK TFSNIPDPLP LFPFTGVGNR MPLVKYEHEE VEISLDAAMA
QKIRNLCRQN RCTTFHFFLA TFQIFLGKWL EVDDLCIGIA DANRSDIKTL STIGFLLNLV
PLRFSALNGK APFSSVLAAA KQTAYNSLAH SKLPFDLLLE ELNLPRSSST SPLFQAFLDY
RQLAVKTPPM LESSAEGEQN FGATAYDVVL DVTDYAMADI KIKWQTQKAL YNTKHTEAMM
ESYMNLLNHF ANSATSSVES APLYRPEDVK AAVEAGQGSQ FDGQWPETLS LKIDDISGKS
PESIALADVS NSFTYSSMNR FIDQIIEELV QGGVKPGDKV GIFQQPSSLW ISSLLAVWRA
GAVYVPLDPR NGVPRLASTV GVVQPQAIIH DNANAKDVSS LAAPASASII NINNVRKKDA
TVAHRPNLST GNSSAIIVSS SGSTGVPKCI EVRHSSLINL FEGDSKTWNL GSAKVLQQSA
YSFDISLDQI MTAFVNGGTL YVASEEERTN PELIAKVIVD NNINYTTATP SEYSNWIGFA
AETLAKASSW RIANVGGEGW NSNLRDSFSN LKLPQLVIRN NYGPAEASVW ATRYPIEYPG
KGTLIPAGPA LPNYSFYIID KKNNVVPTGV QGEILIGGAG VAVGYYKNAE LTKDKFITDK
HATEAHTAKG WNRAYKTGDK GYLTEDGTLI VQGRISGDTQ IKLRGFRIEL EDIESTIVHA
SQGVLTRAVA NVRGDGPASY LVAFAEFADG YPAEEQDAYL SKLISKLPLP QYMRPNIMVP
IVDIPVNAHN KVNRLAIATL PIRTASSDDN LNTELTETAK TIRDIWVDIL PDSIVQNTTL
YASSDFFVLG GNSLLTVRLQ SRLREIYGVF VPLIKIMESS TLSGLSNTLD DLLSNQEINW
DVETALSDEM LSVTPVNPNT TRPKTTDLTV ILTGVSGFIG RHLLQRLIED KNVSAIHCVA
VRNIEMDSPS RQKMKALIAS TNKVQLYPGD LSEPRLGLSE AEFDTLSRKA DMIVHSGANR
SFWSAYDMVR APNVQSTKEL ALMAATALRD SNKVVPFHFM SGSEDAGIEP STDGSNGYVA
SKWASEQFLQ RFADQLGLPV HVHRQLPVPE GRTAQGEELD SILQEFVDVA AKMPELPNPD
TWRGYYDLIP ADRLSDDVVD LAMSGLVSTN NAFSKHSHYS SVRMDIGEVI KKIDSLDEYK
NTDRPLIPAH VWVGKAKIAG FRYQFSTMKM SLQDAEGKNM GFLER
//