ID A0A2N6PEW7_9MICO Unreviewed; 704 AA.
AC A0A2N6PEW7;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Peptidase M14 carboxypeptidase A domain-containing protein {ECO:0000259|PROSITE:PS00132, ECO:0000259|PROSITE:PS00133};
GN ORFNames=CJ198_11840 {ECO:0000313|EMBL:PMB97236.1};
OS Brevibacterium luteolum.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Brevibacteriaceae;
OC Brevibacterium.
OX NCBI_TaxID=199591 {ECO:0000313|EMBL:PMB97236.1, ECO:0000313|Proteomes:UP000235703};
RN [1] {ECO:0000313|EMBL:PMB97236.1, ECO:0000313|Proteomes:UP000235703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UMB0680 {ECO:0000313|EMBL:PMB97236.1,
RC ECO:0000313|Proteomes:UP000235703};
RA Thomas-White K., Kumar N., Forster S., Putonti C., Lawley T., Wolfe A.J.;
RT "Bacterial strain isolated from the female urinary microbiota.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M14 family.
CC {ECO:0000256|ARBA:ARBA00005988}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PMB97236.1}.
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DR EMBL; PNFZ01000008; PMB97236.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N6PEW7; -.
DR OrthoDB; 5240362at2; -.
DR Proteomes; UP000235703; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR000834; Peptidase_M14.
DR InterPro; IPR006970; PT.
DR PANTHER; PTHR11705:SF91; CARBOXYPEPTIDASE A1 (PANCREATIC)-RELATED; 1.
DR PANTHER; PTHR11705; PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B; 1.
DR Pfam; PF00246; Peptidase_M14; 1.
DR Pfam; PF04886; PT; 1.
DR PRINTS; PR00765; CRBOXYPTASEA.
DR SMART; SM00631; Zn_pept; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00132; CARBOXYPEPT_ZN_1; 1.
DR PROSITE; PS00133; CARBOXYPEPT_ZN_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000235703};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..704
FT /note="Peptidase M14 carboxypeptidase A domain-containing
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014801768"
FT TRANSMEM 680..699
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 188..210
FT /note="Peptidase M14 carboxypeptidase A"
FT /evidence="ECO:0000259|PROSITE:PS00132"
FT DOMAIN 365..375
FT /note="Peptidase M14 carboxypeptidase A"
FT /evidence="ECO:0000259|PROSITE:PS00133"
FT REGION 595..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..673
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 704 AA; 74114 MW; 38D258305B077039 CRC64;
MKKTLHRLGA GTAVAALLAS AASAGAAFAA PAGDVLLLTV PADDVESASE TLGDLDIVSA
EGDNVIVLGD QDLADELEKT GASVTAENYA DSLGTRPASA QPAAPAPVPA KLNAAAYDTF
FNGYRTTSAY AQFAQDLASQ YPELVQHVDY GDTFLKQQGQ GGHDLVAVRI TADVADQPEY
ADGQDGKPRF FLGAQTHSRE IITSEMAWRF ATELIDGYGT DAQITSLLDS TEVWVSFQHN
PDSIDVVEQA FADGVDTTPA GDGNPNSASK AWQRKNQNTA GFEDTGAPWS RSQPGIDLNR
NWPYGWGGAS TSSDPSSVLY KGSAPASEPE VAALKDLLED LYGTYDVETT TAAPDERAGT
YIHLHSYSDL ILYPYGFDNT ANVRNADALI AGAFRQSFGN DYATGAPGDV LYNASGGDFD
YAYGKLGVPG YVYEIGTARE GGFFPGFQRA DDYWQKVQPG LRFAAEAAYE PYTASLGGVV
SELTAERQDD GSIIVTGTAT DDAYGQDAGS AARRPAVTQI DDVEIQAAVD RTALDAGEST
GPGEAAVPEA GETVDFEASI AKEGSEQARF VFARARNGSG EYGPWQAVFV DPVEEDEAPE
PTDEPSPDPE PTADPTADPT ATPTGEPSAD PSEDPTSGPT DAPRDDDGKR DDNGKRDDDD
ASRDQDRDDR SQLPRTGAGL WPLAAGAALL AAGGLGVWAS RRRS
//
