ID A0A2N6SPC2_9LACT Unreviewed; 860 AA.
AC A0A2N6SPC2;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:PMC58902.1};
GN ORFNames=CJ205_01665 {ECO:0000313|EMBL:PMC58902.1};
OS Dolosicoccus paucivorans.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Aerococcaceae; Dolosicoccus.
OX NCBI_TaxID=84521 {ECO:0000313|EMBL:PMC58902.1, ECO:0000313|Proteomes:UP000235682};
RN [1] {ECO:0000313|EMBL:PMC58902.1, ECO:0000313|Proteomes:UP000235682}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UMB0852 {ECO:0000313|EMBL:PMC58902.1,
RC ECO:0000313|Proteomes:UP000235682};
RA Thomas-White K., Kumar N., Forster S., Putonti C., Lawley T., Wolfe A.J.;
RT "Bacterial strain isolated from the female urinary microbiota.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PMC58902.1}.
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DR EMBL; PNHE01000004; PMC58902.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N6SPC2; -.
DR STRING; 84521.SAMN04487994_102820; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000235682; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000235682}.
FT DOMAIN 682..698
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 608..615
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 860 AA; 98596 MW; B00C3DE57E6B4802 CRC64;
MSQSSPTPMM KQYFKIKEQY PDAFLFFRLG DFYELFYEDA KEAARILEIT LTARNKNADN
PIPMCGVPHH SSKDYIKKLV EEGHKVAICE QLEDPRTTKG MVKRDVIQVI TPGTIMEEGA
TQANENNYLA TVTESENGYI LSYVDFSTGE TNLTHMNSID QLLQEIETIQ PTELVYKDNA
TDHLIDALKT IKSVYLSSMD STISKSTDPL WELEQATEEE AINLNVLFDY LQSVQKQAFY
HMRPVTRYQL KDYLQMSLQT KIQLELTRSL RTHRRKGSLL WLIDKTKTAM GGRLLHQWLE
KPLIDKKELT TRHEKVSVLL ENFFYRHDLV SFLNHIYDLE RLVTKISLGS ANARDLDQLR
FSLQQIPLIN QILDDLNEQV GHTVFDRLNP LSDLYELLEE TLVDDPPIST TQGDLIKDGV
SDKLDKYRDA LKNGQQWLLD LQQREREKTG LSTLKVGYNR VFGYYIEISR KQSELLEDDV
YERKQTLANT ERFITQELKD IEKVMLEADE KSIALEYELF AELRQQVMPY IEELQFVAQQ
IAQMDVLCNF ATISEEENYV RATLVSHDEG LILKDSRHPV VERLLGKAHF VPNDVTITSQ
QPLLLLTGPN MSGKSTYMRQ VAFCIILNQM GCFVPASQAQ LPIVDQIYTR LGSSDDTASG
QSTFMVEMME TNEAIRHATS NSLLLFDEIG RGTATYDGMA LAEAILYYIA EKVQAATIFS
THYHELTDLD QKISSLRNIH VGAIEENNQV IFQHKILDGP ADKSYGIHVA RLAGLPEEVL
QRSESVLETL EASSYPSRKN DQGIISQVQE LDTPKQMSLF TVEENPNLEK LQQEIETISL
LNLTPLQAMQ YIEQWQQMLK
//
