ID A0A2N6U125_9MICO Unreviewed; 588 AA.
AC A0A2N6U125;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 12.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:PMC75262.1};
GN ORFNames=CJ197_09730 {ECO:0000313|EMBL:PMC75262.1};
OS Brachybacterium sp. UMB0905.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Dermabacteraceae;
OC Brachybacterium.
OX NCBI_TaxID=2069310 {ECO:0000313|EMBL:PMC75262.1, ECO:0000313|Proteomes:UP000235560};
RN [1] {ECO:0000313|EMBL:PMC75262.1, ECO:0000313|Proteomes:UP000235560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UMB0905 {ECO:0000313|EMBL:PMC75262.1,
RC ECO:0000313|Proteomes:UP000235560};
RA Thomas-White K., Kumar N., Forster S., Putonti C., Lawley T., Wolfe A.J.;
RT "Bacterial strain isolated from the female urinary microbiota.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PMC75262.1}.
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DR EMBL; PNHL01000008; PMC75262.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N6U125; -.
DR InParanoid; A0A2N6U125; -.
DR OrthoDB; 9789078at2; -.
DR Proteomes; UP000235560; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000235560};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 67..189
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 268..564
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 588 AA; 62755 MW; FB7229C004A92404 CRC64;
MAAARRRRRG LIPPARVGEP STRHRLLIVM IMVAVLALSG RLVWVQGLDA TALAQEAVEQ
RTVTRVIPAM RGDIVDRRGE VLASSVERYD MWVNQLQVDQ YTGYGDDDPL EGVEAAARDL
APVLGWSTAK TREALTGERG FQYLAKGVEP AVRDAAMSLK IPGIGSDRVP ERIYPAGAVG
GNVLGFVGDD GTAWAGTELT FDEQLRGTDG RTSYERGAQG QIIPTGKQET TEAVDGSDVA
LTIDRDLQWK AQQVAASAME SWGATGASAV VLNARTGEVL ALAEHPTYDP NDPGAADEEY
RGNRAISDVF EPGSTGKLFT FAAAIEEGAV TPESQYEIPY EMWFEGERVK DSHQHPEQRL
TAAGVLKNSS NVGTVQIAET VSPEVRYDYL RAFGLGERTG IELPAEAAGV VHPVSQWSGR
TRYTTAFGHG YSVNALQMVS AVGTFANDGV RVQPSLIQGV RQADGSIKPL GEPEQTRVVS
SETAATMREL MDNAVDDDEH AAAIPGYAVA GKTGTAQVPG GTYTASFIGF APADDPELVV
GVFVFGLNSY ISGSRAAAPA FSELTAFALQ NQGIAPTGQP GRELENEW
//
