ID   A0A2N6UPC1_9ACTO        Unreviewed;       873 AA.
AC   A0A2N6UPC1;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN   ORFNames=CJ187_01360 {ECO:0000313|EMBL:PMC85393.1};
OS   Gleimia hominis.
OC   Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC   Gleimia.
OX   NCBI_TaxID=595468 {ECO:0000313|EMBL:PMC85393.1};
RN   [1] {ECO:0000313|EMBL:PMC85393.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UMB0859 {ECO:0000313|EMBL:PMC85393.1};
RA   Thomas-White K., Kumar N., Forster S., Putonti C., Lawley T., Wolfe A.J.;
RT   "Bacterial strain isolated from the female urinary microbiota.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PMC85393.1}.
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DR   EMBL; PNHU01000001; PMC85393.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2N6UPC1; -.
DR   OrthoDB; 7051771at2; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        173..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        233..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        272..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        300..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        353..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        515..535
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        547..568
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        580..604
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        625..647
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          196..329
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   873 AA;  92775 MW;  E1645243ACF063BE CRC64;
     MSSFLYRTAA WVIRHAKSVL AGWIIVLIAA VGGMVAVGST LGNDFTIPGT QGQQGLDTLD
     DRFPEFAGAS GQVVFGAPKG EDIHRYQSDI EDVAKKISKV PHVIAAPSPF DDTLMDPMVS
     DNNRYAMTQV NFDFGIDELN DASVNQVEKI AHTAQDAGLS VDVGGQIKQV TSIPLSIMEA
     VGVLVALVIL VVTFRSLIAA FIPIATGLLG VGVAMSIIMM LGEAVTISTT TPTLAIMLGL
     AVGIDYSLFI VSRHRDQLGS GMDVKESIPL AIATSGSAVT FAGVTVVIAL AALFVARIPF
     LTIMGLCAAL AVALAVLVAI TALPAILMLL GNRIKPKARK KKKNGFLSRW PKVVTAHPWF
     AILGVVAVLV AMTVPACNLR LGLPDNGVDP VGSAGRDTYD LVAEEFGPGI NGPILVIGDI
     VTSTDPLGLM DDLKGEIESI KGVDHVQLAT PNRTADLGVA VVIPREGPDS IATENLVHEL
     RERAPKWSDD IGIKNTFVTG MAAVKIDVSE RLFDALLPFG VVVVGLSLGL LTIVFRSIWV
     PLKATLGYLL SVGAAFGMTT LVFIDGWGNT ALGINQVGPV ISFMPIILMG VLFGLAMDYE
     LFLVSRMRED YVRTNDPHHS ILTGFRASAP VVIAAALIMI SVFSGFLPGG SFYVQPIAFG
     LAVGVFVDAF LVRMTLVPAV MQLLGAHAWY LPRWMQKILP VFDVEGAAIE ARFEHEKWQE
     EHGQAAARAE SLTVTAGSTP LFENVDLVVR PGEVLRLTGD EAQVHALCSV LAGRLRPDAG
     QAFVGDVSSV DEPGRVLPHV GWIVTGQPVA STGVSLYIVR RALTESETRV LKDNVSGGSA
     VVLGCGPLTG LEVNRVYEFE HLRSAQLQKE ATR
//