ID A0A2N7UGN8_9GAMM Unreviewed; 1020 AA.
AC A0A2N7UGN8;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=C1H70_11540 {ECO:0000313|EMBL:PMR79609.1};
OS Halomonas urumqiensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Halomonas.
OX NCBI_TaxID=1684789 {ECO:0000313|EMBL:PMR79609.1, ECO:0000313|Proteomes:UP000235547};
RN [1] {ECO:0000313|EMBL:PMR79609.1, ECO:0000313|Proteomes:UP000235547}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BZ-SZ-XJ27 {ECO:0000313|EMBL:PMR79609.1,
RC ECO:0000313|Proteomes:UP000235547};
RA Chen C.;
RT "Halomonas endophytica sp. nov., isolated from storage liquid in the stems
RT of Populus euphratica.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PMR79609.1}.
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DR EMBL; PNRG01000026; PMR79609.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N7UGN8; -.
DR OrthoDB; 8552189at2; -.
DR Proteomes; UP000235547; Unassembled WGS sequence.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000235547};
KW Transferase {ECO:0000313|EMBL:PMR79609.1}.
FT DOMAIN 131..329
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
SQ SEQUENCE 1020 AA; 114371 MW; EC8AB1F2D52712C2 CRC64;
MMPTPHKPRR LTPWLILVGL LLTASLATLL VAEARTSRLQ SQELSRYARA LTYSVSPGVS
DLIRHPQHGP FDTRFGYTRL PEFDSRLTSN GFIVERQARF SPALMEYTGY GLFPPFREKT
QAGLTLEECR GQMLYQLRQP AHQYPHFDAV PPLILEILLF IENRELLDTD APNANPAVDW
PRFAKAAVSQ IGQALDIPGQ SAGGSTLATQ IEKYRHSPHG LTATPMEKLR QMISASVRGY
RHGPQTLTAR QDVALDYLNS VPLSAVKGHG EVHGLGDGLW AWFNADFDQF NRLLVPGFNA
PDQHALQGLA VRQAVALMIA QRRPSWYLNT GRDSLERLTD SYLRLLTHAQ ILTTDLRDAA
LDQRLVFRDH QTHPIRHRVG SEKGLQVARL RLANLLGTSL HELDRLDLTA STTLNSDLQR
QVSMYLKQLA DPQFATDIGL VGDRLLWPET TEKVHYSFTL LERSEDGFRV RVQTDNGEQP
FDINAGSKLE LGSTAKLRVL ANYLEVVAEL HARHSGKPAA TLREIPVDRQ DHLSRWVLES
LMANPSMTLS DLLDTAMQRR YSASPSEAFF TGGGRHTFSN FRRQDNGRHP TLEEAMRESL
NLPFVRLLRD LVNYSIHQDE NRRQLLEDDG DPRRQDYLAS FADREGRVFL QRFWRKYQQQ
DSAARLATLV STLQLTDSRL ATVIRYLYPE ATIDEFANLM KAHLPGTPVG SDRLATLYEQ
YAPERHTLTD QGYIARVHPL ELWLVGYLLD APEATYRDAE AASQEQRQEV YGWLFNTRHR
NARDTRIRTM LEVEAFMDIH RRWVRLGYPF DQLVPSLATA LGSSGDRPAA LAELMGIILN
DGIRLPTLRI DDLHFATDTP YETRFVADNS QAVRVMPSEV ASVLRHHLGQ VVEGGTARRL
KGSFQGKDGT LLAVGGKTGT GDNRFETVTR SGQVIDSQAR NRTATFVFHL GEDHFGTLTA
FVPGSEADHF DFTSALPVQV LKGMAPILMP FLTPGGRTHC LPPASPGMLM ADSTAAGGTS
//
