ID A0A2N8N9W2_9BACT Unreviewed; 509 AA.
AC A0A2N8N9W2;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Replicative DNA helicase {ECO:0000256|ARBA:ARBA00021957, ECO:0000256|RuleBase:RU362085};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551, ECO:0000256|RuleBase:RU362085};
GN ORFNames=BHU16_00740 {ECO:0000313|EMBL:PNE25562.1};
OS Tannerella sp. oral taxon 808.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae;
OC Tannerella.
OX NCBI_TaxID=712711 {ECO:0000313|EMBL:PNE25562.1, ECO:0000313|Proteomes:UP000235918};
RN [1] {ECO:0000313|EMBL:PNE25562.1, ECO:0000313|Proteomes:UP000235918}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Cell103 {ECO:0000313|EMBL:PNE25562.1};
RA Beall C.J., Campbell A.G., Griffen A.L., Podar M., Leys E.J.;
RT "Genomics of the uncultivated, periodontitis-associated bacterium
RT Tannerella sp. BU045 (oral taxon 808).";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in initiation and elongation during chromosome
CC replication; it exhibits DNA-dependent ATPase activity.
CC {ECO:0000256|RuleBase:RU362085}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665,
CC ECO:0000256|RuleBase:RU362085};
CC -!- SIMILARITY: Belongs to the helicase family. DnaB subfamily.
CC {ECO:0000256|ARBA:ARBA00008428, ECO:0000256|RuleBase:RU362085}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNE25562.1}.
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DR EMBL; MIQB01000003; PNE25562.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N8N9W2; -.
DR Proteomes; UP000235918; Unassembled WGS sequence.
DR GO; GO:1990077; C:primosome complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-UniRule.
DR CDD; cd00984; DnaB_C; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR036185; DNA_heli_DnaB-like_N_sf.
DR InterPro; IPR007692; DNA_helicase_DnaB.
DR InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR InterPro; IPR007693; DNA_helicase_DnaB-like_N.
DR InterPro; IPR016136; DNA_helicase_N/primase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00665; DnaB; 1.
DR PANTHER; PTHR30153:SF2; REPLICATIVE DNA HELICASE; 1.
DR PANTHER; PTHR30153; REPLICATIVE DNA HELICASE DNAB; 1.
DR Pfam; PF00772; DnaB; 1.
DR Pfam; PF03796; DnaB_C; 1.
DR SUPFAM; SSF48024; N-terminal domain of DnaB helicase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51199; SF4_HELICASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362085};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU362085};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU362085};
KW Helicase {ECO:0000256|RuleBase:RU362085, ECO:0000313|EMBL:PNE25562.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU362085};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362085}; Primosome {ECO:0000256|RuleBase:RU362085};
KW Reference proteome {ECO:0000313|Proteomes:UP000235918}.
FT DOMAIN 195..469
FT /note="SF4 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51199"
SQ SEQUENCE 509 AA; 57361 MW; 4F3F422EAE5963FE CRC64;
MAENNPIRTA RKKPVIVQVS DTGRLQPQAR ELEDAVLGAL MLEQDAFFRV NETLKPESFY
SKTNQLIYKA IVDLAARQEP IDMLTVVDQL KKNGALETIG GPLYISQLTE NVASAAHLER
HAQIVAEKYL ARELIRYTGE IQGKAYDETV EMKDLMQEAE GELFRISQQN IRNEAVQINP
VIKEARDLLE RAANRKEGLS GLPSGFADLD KITSGWQNSD LVIIAARPAM GKTAFVLSMA
RNMAVTFKVP VAMFSLEMSN VQLVNRLIIN VCELPGEKIK SGRLEKYEWE QLEYKIKDLY
DAPIYVDDTP SLSIFELRTK ARRLVREHKI QCIFIDYLQL MNASGMTFGS REQEVSTISR
SLKGLAKELN IPIIALSQLN RGVEARQGIE GKRPQLADLR ESGAIEQDAD MVCFIHRPEY
YKIYEDERGN SLAGIAEIIV AKHRNGATGD IRLRFKSEFA KFINLSEDQA VREYASSMNK
EGEETKVIPI TAPNVEDFIA SQDDEPVPY
//
