ID A0A2N8NA69_9BACT Unreviewed; 600 AA.
AC A0A2N8NA69;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=BHU16_00585 {ECO:0000313|EMBL:PNE25647.1};
OS Tannerella sp. oral taxon 808.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae;
OC Tannerella.
OX NCBI_TaxID=712711 {ECO:0000313|EMBL:PNE25647.1, ECO:0000313|Proteomes:UP000235918};
RN [1] {ECO:0000313|EMBL:PNE25647.1, ECO:0000313|Proteomes:UP000235918}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Cell103 {ECO:0000313|EMBL:PNE25647.1};
RA Beall C.J., Campbell A.G., Griffen A.L., Podar M., Leys E.J.;
RT "Genomics of the uncultivated, periodontitis-associated bacterium
RT Tannerella sp. BU045 (oral taxon 808).";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNE25647.1}.
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DR EMBL; MIQB01000002; PNE25647.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N8NA69; -.
DR Proteomes; UP000235918; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000235918}.
FT DOMAIN 209..327
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 417..559
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 600 AA; 66720 MW; DCDC6F44BB591F62 CRC64;
MSDIIHLLPD HIANQIAAGE VIQRPASVVK ELMENAVDAG AMHITVHIKE AGRALIQVID
DGKGMSETDA RMAFERHATS KIAAAEDLFS LRTMGFRGEA LPSIAAVAQV ELRTRARGTE
LGTRLTIEGS ELIDIAPDAC PEGAIFSVKN LFFNIPARRK FLKSNETEFR NIMTEFERVV
LANPALTFRL MHNDTEVMNL PAAPTRRRIV DVFGKHFNQR LLPVETTTSL VKIEGFIGRI
DTVRRRGYRN YFFVNGRYMR HPYFHKAVTQ AYERLTPPGE LPDYFIYLTL DPAGIDVNIH
PTKTEIKFEN EQPIWQILAS AVREALGKFN AVPSIDFDTE GALDIPIYNP AADHTAVRQP
AVEVNPHYNP FRSAPAPLAP DRNWEKLYQD FTNESPSPTP DAPAAPLFPE PTTATSACFQ
YKNRYILTAL KSGLAMIDQH RAHVRILYDR YVRNVREHTA VSQKLLFPEL VELTPTEAAL
LPSLLDGLHR LGFELSPMGG NSYSVTAVPS GLRDVKASEL LKELVDGTAD TPDAVGDEMA
EALALSLARS AAIRPGRSLT TEEMEEMVAT LFSTESNRIT PDGKPVLIIL TDDELATRFR
//
