ID A0A2N8ZCS9_9VIBR Unreviewed; 1152 AA.
AC A0A2N8ZCS9;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969,
GN ECO:0000313|EMBL:SON49709.1};
GN ORFNames=VTAP4600_A1730 {ECO:0000313|EMBL:SON49709.1};
OS Vibrio tapetis subsp. tapetis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=1671868 {ECO:0000313|EMBL:SON49709.1, ECO:0000313|Proteomes:UP000235828};
RN [1] {ECO:0000313|EMBL:SON49709.1, ECO:0000313|Proteomes:UP000235828}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Vibrio tapetis CECT4600 {ECO:0000313|EMBL:SON49709.1};
RA Banno H., Chua N.-H.;
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR EMBL; LT960611; SON49709.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2N8ZCS9; -.
DR KEGG; vta:A1730; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000235828; Chromosome a.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR CDD; cd18810; SF2_C_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11140; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR048635; MFD_D3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21132; MFD_D3; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000235828}.
FT DOMAIN 618..779
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 801..954
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1152 AA; 129827 MW; 61B068837CC8B1CF CRC64;
MPKSSLLSLA LPTKAGDKKH VGNLTGASLS IAVAELADAH KGHTLLVVPD PQMALKLSGE
VEQFTEQDVQ LFPDWETLPY DNFSPHQDII SDRIAHLYRL PSQKNGITVV PISTLLQKQS
PRDFLLQHTL MVKAGDRYNI ETLRIQLDKS GYRNVDQVFG PGEYASRGSI IDLYPTGSTD
PYRIDFFDDE IDSIRTFDAE SQRSIEDIGH IRLLPAHEFP TTETAIEAFR SRWRQRFEAR
REPESVYMQV SKGTWPSGIE YWQPLFFDET ETLFDYIADN TLLISIGDLE PSIDHFLADV
DHRFEQRKVD PLRPLLPPEE LWLKKDELFS QLKVMPQARL NVKKIEEKAG RSNPAIAPLP
ALHAQHQNKE PLAALRQFIE QFEGKIVFSV ESEGRREALL ELLQGIKLKP TATDSLTKAS
KGKARVSLIL GVAEHGFIHR DPNIALICES DLLGDRVIQR RKKDRKAVNS DTVIRHLAEL
KPGQPVVHLD HGIGRYIGLQ TLEAGGLVTE YVTLEYQNEA KLYVPVASLN LISRYSGGAE
DKAPIHKLGG ETWVKARRKA AEKVRDVAAE LLDVYAKREL KPGHKFKLDR GQYATFKSSF
PFEETDDQAM AINAVMSDMC QAKAMDRLVC GDVGFGKTEV AMRAAFIATD NNKQVAVLVP
TTLLAQQHFE NFRDRFANLP IRVEVLSRFK SAKEQKQILA DLSEGKVDII IGTHKLLQDD
IKFRDLGLLV VDEEHRFGVR QKEKVKAMRA DVDILTLTAT PIPRTLNMAM SGMRDLSIIA
TPPARRLAIK TFVRESEDSV VREAILREIM RGGQVYFLHN QVETIEKVAA DLEKLIPEAR
VTVAHGQMRE RELERVMNDF YHQRFNLLVC TTIIETGIDV PTANTIIMDR ADNLGLAQLH
QLRGRVGRSH HQAYAYLLTP HPKAMSKDAI KRLDAIASLE DLGAGFTLAT HDLEIRGAGE
LLGDDQSGQI HSVGFTLYME MLEQAVEALK EGKEPSLDEL LRDQTEVELR LPALLPDDYI
PDVNMRLSMY KRIASVSNLN ELAEMKVELI DRFGPLPDAT KNLLSVSEIK LQAGQLHVKK
LEAHPKGGFV EFYPTADINP AYLVKLLQST PQKFGMEGPT KLKFTVPLTD RRERIRFIND
LLEQFAQNRL PA
//
