ID A0A2P1CGW9_9CAUD Unreviewed; 595 AA.
AC A0A2P1CGW9;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=DNA polymerase I {ECO:0000313|EMBL:AVJ50424.1};
GN Name=43 {ECO:0000313|EMBL:AVJ50424.1};
GN ORFNames=SEA_MPLANT7149_43 {ECO:0000313|EMBL:AVJ50424.1};
OS Mycobacterium phage MPlant7149.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Fromanvirus.
OX NCBI_TaxID=2099635 {ECO:0000313|EMBL:AVJ50424.1, ECO:0000313|Proteomes:UP000240762};
RN [1] {ECO:0000313|EMBL:AVJ50424.1, ECO:0000313|Proteomes:UP000240762}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Thomas A., Piccirillo M., Barshop W.D., Shaffer C.D., Weston-Hafer K.A.,
RA Russell D.A., Pope W.H., Betsko A.J., Stoner T.H., Jacobs-Sera D.,
RA Hatfull G.F.;
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
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DR EMBL; MG925351; AVJ50424.1; -; Genomic_DNA.
DR Proteomes; UP000240762; Genome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00023109};
KW Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}.
FT DOMAIN 15..192
FT /note="3'-5' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00474"
FT DOMAIN 372..555
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 345..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 595 AA; 66118 MW; DD55A7C91EAC9254 CRC64;
MKQHRYQIKD ETVLVNVVEH EDDLDGFEGF IRSNLRILGL DTETTDLGIY KPDFGIRLIQ
FGNPWESWVL PVERGGVFVG AAVTALQKVQ RFVIHNAAFD LQVIERTLGV PMEQMWPKVE
DTKIYSHLVD PRAYKEGGTG HKLEELTKFY IDPVTAEEVK ASMARLAKKH KTTKDKIWAL
VDLDDPDYEL YAGMDTILVS RLLGKVAPLV PESSHKLIPY EHKLAEVMSY VERTGFLLDV
DYSEKLSADM LRKAEHYTAV ARYAYGVDSV NSTEKLADGL ERTGVKIKGR TATGKRQVNA
ELLEALAEEG NALAKAAIEA KKWGSWEKTW VRNFIERRDA NDRVHPGINP LQARTGRMST
SNPSAQNLPA NDWMVRRCFI ADPGELMVSV DYQAQELRVL AALADDRTMK RAFEENADLH
QITADASGVD RKVGKMVNFA YAYGSGPANI AAQAGISFQE AKKVIAGFEK SYPGVTALSK
SLQQEAAARG YIVTPTGRRL PVDPDRGYAA LNYAIQSASR DVTASAVIRL HEAGLTRNMR
LVVHDEVLAS VPALEAESMA KEIGRIMEME FRGVHIGTDP EVQGPTWGHG YGAPY
//
