ID A0A2P2E188_9LEPT Unreviewed; 564 AA.
AC A0A2P2E188;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=LPTSP4_21840 {ECO:0000313|EMBL:GBF50657.1};
OS Leptospira ryugenii.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1917863 {ECO:0000313|EMBL:GBF50657.1, ECO:0000313|Proteomes:UP000245133};
RN [1] {ECO:0000313|EMBL:GBF50657.1, ECO:0000313|Proteomes:UP000245133}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YH101 {ECO:0000313|EMBL:GBF50657.1,
RC ECO:0000313|Proteomes:UP000245133};
RA Nakao R., Masuzawa T.;
RT "Novel Leptospira species isolated from soil and water in Japan.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GBF50657.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BFBB01000007; GBF50657.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P2E188; -.
DR OrthoDB; 9802848at2; -.
DR Proteomes; UP000245133; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:GBF50657.1};
KW Helicase {ECO:0000313|EMBL:GBF50657.1};
KW Hydrolase {ECO:0000313|EMBL:GBF50657.1};
KW Nucleotide-binding {ECO:0000313|EMBL:GBF50657.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245133}.
FT DOMAIN 198..354
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 406..562
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 564 AA; 64044 MW; C38C2A124555D1FC CRC64;
MAKPLTVQSD KTMLLEVDNP EFEACRDLIS KFAELEKSPE YMHTYRISPL SLWNAASIKM
TADEIIDGLV QFARYSVPKN VINEVREQIS RYGKVKLVKE ESGELYIISN EAGFITEIAN
NRAVQPFVDG MEGDKIRIKK EYRGHIKQAL IKIGFPVEDL AGYDEGNKYP FNLRPVTKGG
IKFGMRDYQR ASVEAFHAGG RNEGGSGVVV LPCGAGKTIV GMGVMQIVGA ETLILVTNTL
SIRQWRNEIL DKTDIPESDI GEYSGELKEI KPITIATYNI LTHRKKKGGD FTHFHIFSAN
NWGLIVYDEV HLLPAPVFRM TSELQAKRRL GLTATLVRED GLEEDVFSLI GPKKYDVPWK
ELEAKSWIAE ANCVEIRVPM EDDLRMRYSV ADDREKFRLA SENPEKLRAI DYILKKHASN
NILVIGQYIN QLEEISQKFK IPLITGKTPL PERQELYQAF RSGQIKQLVV SKVANFSIDL
PDANIAIQVS GTFGSRQEEA QRLGRILRPK SNDNTAIFYS LISRDTNEER FGQNRQLFLT
EQGYEYEIYT LDQFKETVPE EALK
//
