ID A0A2P2E215_9LEPT Unreviewed; 662 AA.
AC A0A2P2E215;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:GBF50921.1};
GN ORFNames=LPTSP4_24490 {ECO:0000313|EMBL:GBF50921.1};
OS Leptospira ryugenii.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1917863 {ECO:0000313|EMBL:GBF50921.1, ECO:0000313|Proteomes:UP000245133};
RN [1] {ECO:0000313|EMBL:GBF50921.1, ECO:0000313|Proteomes:UP000245133}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YH101 {ECO:0000313|EMBL:GBF50921.1,
RC ECO:0000313|Proteomes:UP000245133};
RA Nakao R., Masuzawa T.;
RT "Novel Leptospira species isolated from soil and water in Japan.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GBF50921.1}.
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DR EMBL; BFBB01000007; GBF50921.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P2E215; -.
DR OrthoDB; 343514at2; -.
DR Proteomes; UP000245133; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR019494; FIST_C.
DR InterPro; IPR013702; FIST_domain_N.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF08495; FIST; 1.
DR Pfam; PF10442; FIST_C; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00897; FIST; 1.
DR SMART; SM01204; FIST_C; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000245133};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 485..612
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 662 AA; 73845 MW; E0A789E0BEE4B855 CRC64;
MSIKSLCSEN LDQLNQQILD LKSVGFEPTL GICFVNDRMI EPKISELFKK HNIQVMGACC
SEGIETDRVY KKNIVTLLIE IPKEFFKIHI IDPNLDEIDI DSFIYGNELR KLAQVTFDEP
ALLLLVAPGD LQIKTEKLLE GIFSEDNSIP VFGGLASSLG VLRNPPIFDQ NNLYALGIAC
LIIDQTFLNV QGITIGGWTE LGTEKKITKS SANVVYEIDG IPATEYYYSY FNIAPPKEKQ
AFNNLNPDLL AASEYPILIT KADGSRVVRA AIKFDMEEKT VHYGGDIPQY ANIRFCSPNL
TDTMMNTLNQ MIEFKEARIS DCPDGILLFN CAVRSRAFGP NLNKEIAILQ KIWNSPLVGF
NSWGEIGNTQ GEGCNFHNTV ISAVTLTFKQ KSNQTKMSHH LSQEELISLV NAEADLQPDF
DLRKEWEQLQ REKRILSHFL RITASDLEKE KKAREELLFN TLPESIAKRL ISGEVTIADS
ANQVSVLFAD LVGFTSLSSK LKAETLVSLL NDLFSEFDTL ANRYGIEKIK TIGDAYMAVA
GVPETLSDHA DAVCEMAKQM FQVISNINAI YQYDLNLRVG VNSGPVIAGV IGKKKHSYDL
WGKTVNMAQR MEAHAPNGSI QISTSTYDLL KHKDGWKRVA SVDLKGIGKT STYIYSVFPT
KT
//
